确定新生儿血清甘胆酸参考范围对临床的价值  

The clinical value of determining the reference range of neonatal serum glycocholic acid

作　　者：卢立红[1] Lu Lihong(Department of Laboratory,the Maternal and Infant Hospital of Liaoyuan City,Jilin Liaoyuan 136200)

机构地区：[1]辽源市妇婴医院检验科,吉林辽源136200

出　　处：《中国社区医师》2021年第12期109-110,共2页Chinese Community Doctors

摘　　要：目的:分析确定新生儿血清甘胆酸(CG)参考范围对肝胆疾病及黄疸的临床价值。方法:选取2018年1月-2020年1月妇产科出生的新生儿140例,将足月儿胆红素<221μmol/L,早产儿胆红素<256μmol/L,作为对照组;将足月儿胆红素>221μmol/L,早产儿胆红素>256μmol/L,作为研究组。两组新生儿均进行CG含量检测,并对比检测结果。结果:研究组出现溶血性黄疸、感染性黄疸、肝胆疾病等不同症状的新生儿血清CG含量显著高于对照组,差异有统计学意义(P<0.05);感染性黄疸与溶血性黄疸新生儿CG含量比较,差异无统计学意义(P>0.05);肝胆疾病与感染性黄疸新生儿CG含量比较,差异有统计学意义(P<0.05)。结论:确定新生儿血清甘胆酸的参考范围,能够有效反映新生儿患肝胆疾病及黄疸的状况,可作为诊断的参考依据。Objective:To explore the clinical value of determining the reference range of neonatal serum glycocholic acid(CG)for hepatobiliary diseases and jaundice.Methods:From January 2018 to January 2020,140 newborns born in obstetrics and gynecology department were selected,and cases with bilirubin in term infants less than 221μmol/L and that in preterm infants less than 256μmol/L were used as the control group.Cases with bilirubin in term infants more than 221μmol/L and that in preterm infants more than 256μmol/L were used as the study group.The content of CG was detected in both groups,and the results were compared.Results:In the study group,the serum CG levels of newborns with hemolytic jaundice,infectious jaundice,hepatobiliary diseases and other symptoms were significantly higher than those in the control group,the difference was statistically significant(P<0.05).There was no significant difference in CG content between newborns with infectious jaundice and hemolytic jaundice(P>0.05).There was significant difference in CG content between newborns with hepatobiliary diseases and those with infectious jaundice(P<0.05).Conclusion:To determine the reference range of neonatal serum glycocholic acid can effectively reflect the status of neonatal hepatobiliary diseases and jaundice,which can be used as a reference for diagnosis.

关 键 词：新生儿 甘胆酸 参考范围 黄疸 临床价值 

分 类 号：R446.1[医药卫生—诊断学] R722.1[医药卫生—临床医学]