酸性核质DNA结合蛋白1的研究进展  

Research progress of acidic nucleoplasmic DNA-binding protein 1

作　　者：崔亚婷 勾文峰 魏会强[2] 于江[2] 侯文彬 李祎亮[2] CUI Ya-ting;GOU Wen-feng;WEI Hui-qiang;YU Jiang;HOU Wen-bin;LI Yi-liang(Tianjin University of Traditional Chinese Medicine,Tianjin 301617;Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, CAMS & PUMC, Tianjin 300192, China)

机构地区：[1]天津中医药大学,天津301617 [2]中国医学科学院北京协和医学院,放射医学研究所,天津市放射医学与分子核医学重点实验室,天津300192

出　　处：《基础医学与临床》2021年第5期753-757,共5页Basic and Clinical Medicine

基　　金：中国医学科学院医学与健康科技创新工程(2016-I2M-3-022);中央高校基本科研业务费专项(3332020057);天津市科技计划(18ZXXYSY00110);天津市自然科学基金(18JCQNJC09500)。

摘　　要：酸性核质DNA结合蛋白1(And-1/WDHD1)是一种天然嵌合蛋白,其包含WD40重复序列(WD-repeat)和高迁移率组蛋白框结构域(HMG-box motif)两大蛋白家族特性。And-1在多种肿瘤细胞中过表达,在整个细胞周期过程中参与了预复制复合体(Pre-RC)的组装、DNA复制、检查点激活、DNA修复以及姐妹染色单体内聚等多种功能调控。And-1可作为细胞周期调控的新型靶点,用于广谱抗癌新药的开发。本文重点针对近年来And-1的结构特征、生化功能及在癌中的潜在作用等研究进行综述,以期望为And-1进一步的研究和新药开发提供参考。Acidic nucleoplasmic DNA-binding protein 1(And-1/WDHD1)as a natural chimerical protein,is characterized by containing the WD-repeat and the HMG-box motif families.And-1 is over-expressed in multiple tumors and involved in the whole cell cycle containing prereplication complex(Pre-RC)assembly,DNA replication,checkpoint activation,DNA repair and sister chromatid cohesion establishment.As a novel target for cell cycle regulation,And-1 can be used in the development of broad-spectrum anti-cancer drugs.This article focuses on the research on the structural characteristics,biochemical functions and potential roles of And-1 in cancer in recent years,in order to provide references for the further research of And-1 and the development of new drugs.

关 键 词：酸性核质DNA结合蛋白(And-1) WD40重复序列(WD-repeat) 高迁移率组(HMG) 新型靶点 

分 类 号：R34[医药卫生—基础医学]