表面增强拉曼散射方法检测公共安全类毒物的研究进展  

Research Progress of Surface Enhanced Raman Scattering Method for Detection of Public Safety Poisons

作　　者：林东岳[1,2] 何遥 董荣录 杨良保 LIN Dong-yue;HE Yao;DONG Rong-lu;YANG Liang-bao(Medical Physics Technology Center,Institute of Health and Medical Technology,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,China;Scinece Island Branch,Graduate School of USTC,University of Science and Technology of China,Hefei 230026,China;Institutes of Physical Science and Information Technology,Anhui University,Hefei 230601,China)

机构地区：[1]中国科学院合肥物质科学研究院健康与医学技术研究所医学物理技术中心,安徽合肥230031 [2]中国科学技术大学研究生院科学岛分院,安徽合肥230026 [3]安徽大学物质科学与信息技术研究院,安徽合肥230601

出　　处：《分析测试学报》2021年第4期448-455,共8页Journal of Instrumental Analysis

基　　金：国家自然科学基金资助项目(61605221)。

摘　　要：公共安全类毒物直接威胁人们的生命健康安全。表面增强拉曼散射(SERS)技术的超灵敏特点为复杂基质中痕量毒物的快速检测提供了分析策略,极大地拓展了其应用范围,有着广阔的应用前景。该文综述了SERS技术在公共安全类物质检测方面的研究进展,包括对节球藻毒素、芥子气、琥珀胆碱、甲基对硫磷、氰化物、汞离子、亚硝酸盐等毒物的检测。从基底种类的选择和评估、检测限、重复性和实际应用的角度介绍了检测体系的建立过程。分析了这些方法及其在应用中面临的技术挑战与机遇,展望了SERS技术解决现场实际检测难题的发展方向。Common poisons related to public safety may directly threaten people?s life,health and safety in certain ordinary scenarios.Meanwhile,the ultra-sensitivity detection characteristic of surface enhanced Raman scattering(SERS)technique could provide very effective analysis strategy and idea for the rapid detection of ultra-trace-level toxicants in complex matrix systems,greatly expanding the practical application scope of this technique,which has a very broad practical application prospect.The progress of a series of basic research results is reviewed in this article,based on SERS technique in the rapid and accurate detection of representative public safety toxic substances,and common toxic target molecules including nodular toxin,mustard gas,and chlorinated amber choline,methyl parathion,cyanide,mercury ion,nitrite and other representative poisons are introduced.From the perspectives of selection and evaluation of different types of SERS substrates,performance evaluation of detection limits,scope of repeatability investigation and practical applications,the SERS spectra of typical target poisons are introduced,as well as the establishment of the surface-enhanced Raman scattering detection system,related parameters and system analysis process.The detection methods for these typical toxicants,and the technical challenges and some possible opportunities they might meet in pratical application are specifically analyzed.Finally,the future development direction for SERS technique to solve the difficult problems of on-site actual detection is looked forward to.

关 键 词：表面增强拉曼散射 基底 毒物 检测限 灵敏度 

分 类 号：O657.3[理学—分析化学]