生物样品中γ-羟基丁酸的检验方法与阈值研究  

Research on Detection Methods and Cut-off Values ofγ-Hydroxybutyric Acid in Biological Samples

作　　者：李润康 何洪源[1] 李佳宜 张云峰[2] 任昕昕[2] LI Run-kang;HE Hong-yuan;LI Jia-yi;ZHANG Yun-feng;REN Xin-xin(School of Investigation,People's Public Security University of China,Beijing 100038,China;Institute of Forensic Science,Ministry of Public Security,Beijing 100038,China)

机构地区：[1]中国人民公安大学侦查学院,北京100038 [2]公安部物证鉴定中心,北京100038

出　　处：《分析测试学报》2021年第4期488-494,共7页Journal of Instrumental Analysis

基　　金：中央级公益性科研院所基本科研业务费项目(2020JB002)。

摘　　要：γ-羟基丁酸是一种内源性物质,自20世纪60年代开始在临床中使用,由于其娱乐滥用性受到人们的广泛关注。该文介绍了γ-羟基丁酸的性质与应用、体内代谢和转化,综述了生物样品中γ-羟基丁酸的前处理和检测方法,以及体内γ-羟基丁酸阈值的最新研究进展,以期为法庭科学领域侦破相关案件提供参考和借鉴。γ-Hydroxybutyric acid is an endogenous substance,which has been used in clinical practice since the 1960 s,and has attracted extensive attention due to its recreational misuse.In this paper,the metabolism and transformation in vivo,properties and applications ofγ-hydroxybutyric acid have been carried on the simple overview.In addition,the recent development of research in pretreatments and analysis methods for determination of GHB in biological samples has been reviewed in details,as well as the latest research progress of cut-off values ofγ-hydroxybutyric acid in vivo,in order to provide a reference or model for forensic science field to deal with related cases.

关 键 词：Γ-羟基丁酸 检验方法 阈值研究 综述 

分 类 号：O657.7[理学—分析化学]