猪肺磷脂注射液治疗新生儿胎粪吸入性肺炎的临床效果研究  

Study on the clinical effect of poractant alfa injection on neonatal meconium aspiration pneumonia

作　　者：李培文[1] LI Pei-wen(Department of Neonatology,First People’s Hospital of Tancheng County,Linyi 276100,China)

机构地区：[1]郯城县第一人民医院新生儿科,276100

出　　处：《中国现代药物应用》2021年第8期104-106,共3页Chinese Journal of Modern Drug Application

摘　　要：目的研究猪肺磷脂注射液治疗新生儿胎粪吸入性肺炎的临床效果。方法56例新生儿胎粪吸入性肺炎患儿,按照随机数字表法分为参照组和实验组,各28例。参照组患儿给予常规方式治疗,实验组患儿给予猪肺磷脂注射液治疗。观察比较两组患儿治疗后的炎性因子水平、临床症状消失时间、临床疗效及不良反应发生情况。结果实验组患儿白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α水平均低于参照组,差异具有统计学意义(P<0.05)。实验组患儿肺部湿啰音消失时间为(8.71±1.65)d、发绀消失时间为(2.48±0.53)d、呼吸困难缓解时间为(4.37±1.26)d,均短于参照组的(11.46±2.40)、(5.13±0.75)、(6.70±1.59)d,差异具有统计学意义(P<0.05)。实验组患儿总有效率92.86%高于参照组的67.86%,差异具有统计学意义(P<0.05)。实验组患儿不良反应发生率明显低于参照组,差异具有统计学意义(P<0.05)。结论新生儿胎粪吸入性肺炎患儿采用猪肺磷脂注射液治疗临床疗效显著,其能够优化炎性指标,改善患儿的临床症状,减少不良反应发生,值得推广。Objective To study the clinical effect of poractant alfa injection on neonatal meconium aspiration pneumonia.Methods A total of 56 cases of neonatal meconium aspiration pneumonia were divided into reference group and experimental group according to random numerical table,with 28 cases in each group.The reference group was treated with conventional therapy,and the experimental group was treated with poractant alfa injection.The levels of inflammatory factors and disappearance time of clinical symptoms after treatment,clinical efficacy and occurrence of adverse reactions were compared between the two groups.Results The levels of interleukin-6,interleukin-8 and tumor necrosis factor-αof the experimental group were all lower than those of the reference group,and the difference was statistically significant(P<0.05).The disappearance time of pulmonary rales(8.71±1.65)d,disappearance time of cyanosis(2.48±0.53)d and remission time of dyspnea(4.37±1.26)d of the experimental group were all shorter than(11.46±2.40),(5.13±0.75)and(6.70±1.59)d of the control group,and the difference was statistically significant(P<0.05).The total effective rate 92.86%of the experimental group was higher than 67.86%of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions of the experimental group was obviously lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Poractant alfa injection shows significant clinical efficacy for neonatal meconium aspiration pneumonia,which can optimize the indicators,improve the clinical symptoms of children and reduce the occurrence of adverse reactions.It is worthy of promotion.

关 键 词：猪肺磷脂注射液 新生儿胎粪吸入性肺炎 临床疗效 不良反应 

分 类 号：R722.1[医药卫生—儿科]