醇类防腐剂对皮肤常驻菌的抑制作用  

Inhibitory Effect of Alcohol Preservatives on Skin Resident Bacteria

作　　者：宋静 SONG Jing(Guangzhou Guangmann Biotech Co.,Ltd.,Guangdong guangzhou 510000)

机构地区：[1]广州广曼生物科技有限公司,广东广州510000

出　　处：《生物化工》2021年第2期33-35,39,共4页Biological Chemical Engineering

摘　　要：目的:研究化妆品中新型替代型醇类防腐剂对皮肤常驻菌的抑制作用。方法:将皮肤常驻菌表皮葡萄球菌、疮疱丙酸杆菌、干酪乳杆菌、白色念珠菌和糠秕马拉色菌悬液分别与不同浓度的1,2-己二醇、1,2-戊二醇混合培养6 h、12 h、24 h后,进行菌落总数测定,以细菌杀灭对数值作为评价指标,评价抑菌效果。结果:0.5%~1.0%的1,2-己二醇和1,2-戊二醇在24 h内对5种皮肤常驻菌均未表现出任何抑制作用;在2.0%浓度下,随着作用时间延长,二者对皮肤常驻菌表现出一定的抑菌作用。结论:高浓度的1,2-己二醇和1,2-戊二醇均对皮肤常驻菌有一定抑制作用。Objective:To study the inhibitory effect of new substituted alcohol preservatives in cosmetics on skin resident bacteria.Methods:Staphylococcus epidermidis,Propionibacterium oxysporum,Lactobacillus casei,Candida albicans and Malassezia furfur were mixed with different concentrations of 1,2-hexanediol and 1,2-pentanediol for 6 h,12 h and 24 h,respectively.The total number of colonies was determined,and the logarithm of bacteria killing was used as the evaluation index to evaluate the antibacterial effect.Results:0.5%~1.0%1,2-hexanediol and 1,2-pentanediol did not show any inhibitory effect on five kinds of skin resident bacteria within 24 hours;at 2.0%concentration,they showed certain inhibitory effect on skin resident bacteria with the extension of action time.Conclusion:high concentration of 1,2-hexanediol and 1,2-pentanediol have certain inhibitory effect on skin resident bacteria.

关 键 词：1 2-己二醇 1 2-戊二醇 化妆品 替代型防腐剂 皮肤常驻菌 抑制作用 

分 类 号：TQ658[化学工程—精细化工]