大分子药物透皮递送策略研究进展  

Research progress in transdermal delivery of macromolecule drugs

作　　者：王菁华 程曼曼 施沁青 尹莉芳[1] 秦超[1] WANG Jing-hua;CHENG Man-man;SHI Qin-qing;YIN Li-fang;QIN Chao(China Pharmaceutical University,Nanjing 211100)

机构地区：[1]中国药科大学,南京211100

出　　处：《中南药学》2021年第4期671-678,共8页Central South Pharmacy

基　　金：国家自然科学基金资助项目(No.81871477)。

摘　　要：大分子药物如多肽、蛋白质、抗体、聚糖与核酸等在肿瘤、心脑血管疾病和自身免疫疾病等重大疾病的治疗中有极其重要的作用。然而这些大分子药物,由于其分子量大、独特的亲水性和带电状态,通常表现出相对较低的通透性,很难通过皮肤的角质层。近年来,随着对大分子药物促渗方法研究的不断深入,基于物理、化学、纳米载体等方法的生物大分子透皮递送研究取得了很大进展,本文对相关研究进行系统评述。Macromolecular drugs,such as peptides,proteins,antibodies,glycans and nucleic acids,play an important role in the treatment of major diseases such as tumors,cardiovascular and cerebrovascular diseases and autoimmune diseases.Due to the high molecular weight of these macromolecules,unique hydrophilicity and electric charge state,these macromolecules usually show relatively low permeability,and are difficult to pass through the stratum corneum of the skin.In recent years,with the development in macromolecular drug penetration promotion,great progress has been made in biological macromolecular transdermal delivery based on physical,chemical and nanocarrier methods.This paper systematically reviews related research.

关 键 词：经皮给药 大分子药物 微针 激光 低频声电泳 离子液体 透皮肽 纳米载体 

分 类 号：R94[医药卫生—药剂学]