基于文献数据挖掘中医药治疗卒中相关性肺炎的用药规律分析  

Study on Traditional Chinese Medicine Prescription Rules of Stroke-associated Pneumonia Based on Data Mining

作　　者：罗杰莲 郭绮华 杨杰聪 李梦真 李卓 郭建文[2] Luo Jielian;Guo Qihua;Yang Jiecong;Li Mengzhen;Li Zhuo;Guo Jianuen(Guangzhou University of Chinese Medicine,Guangdong,Guangzhou 510405,China)

机构地区：[1]广州中医药大学,广东广州510405 [2]广东省中医院,广东广州510120

出　　处：《中国中医急症》2021年第4期570-574,共5页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81974559);广东省重点领域研发计划项目:岭南中医药现代化(2020B1111100009);广东省中医院中医药科学技术研究专项(YN2018ML06);广东省基础与应用基础研究基金项目(2020A1515010992)。

摘　　要：目的分析中医药治疗卒中相关性肺炎处方的用药配伍规律,为临床治疗提供依据。方法筛选PubMed、Web of Science数据库、中国知网、万方、维普、中国生物医学文献数据库所收录治疗卒中相关性肺炎处方,并运用SPSS 26.0和SPSS Modeler14.1软件对纳入的中药处方的组方进行中药频次分析、性味归经分析、系统聚类及关联规则分析。结果共纳入89篇合格的文献,统计中药处方90首,中药共118味。中药使用频数前3位为甘草、半夏、黄芩。中药四气百分比前3名分别为寒、温、平,中药五味排名前3名分别为苦、甘、平,中药归经百分比最高的为肺,其次为脾、胃。聚类树状图可分为3个聚类方,以黄芩、瓜蒌、半夏为基础处方,聚类冰柱图可分为5个有效聚类群,对高频药物进行关联规则分析得出23条药对及药组。结论中药治疗卒中相关性肺炎多从痰论治,实则以清热化痰、通腑化浊为法;虚则益气化痰,培土生金。Objective:To analyze the traditional Chinese medicine prescription rules on treating stroke-associated pneumonia(SAP)and provide research basis for clinical treatment.Methods:The prescription for treating SAP were retrieved from databases such as PubMed,Web of Science,China National Knowledge Infrastructure(CNKI),Wanfang,VIP,and Chinese Biomedical Literature Database(CBM).Data analysis was conducted on the distribution,frequency,clustering and association rules by SPSS 26.0 and SPSS Modeler14.1.Results:A total of 89 eligible literatures,90 effective traditional Chinese medicine prescriptions and 118 kinds of herbs were included.The top three frequencies of Chinese materia medica were Glycyrrhizae radix et rhizoma,Pinellia Rhizome,Radix Scutellariae.The top three proportions of 4 qi in Chinese materia medica were cold,warm,and flat.The top three proportions of 5 flavors of Chinese materia medica were bitter,sweet,and flat.The highest proportion of channel tropism of Chinese materia medica was the lung,followed by the spleen and stomach.The clustering pedigree chart could be divided into 3 clustering prescriptions,with Radix Scutellariae,Fructus Trichosanthis and Pinellia Rhizome making up of the principal prescription.The clustering icicle graph could be divided into 5 effective clustering groups,and the association rule analysis resulted in 23 medicine pairs and groups.Conclusion:The treatment of SAP with traditional Chinese medicine is mostly based on phlegm.The therapeutic principle of treating SAP excessive syndrome is clearing heat,eliminating phlegm and relaxing the bowels,while for deficiency syndrome,it is supplementing qi to eliminate phlegm and reinforcing earth to strengthen metal.

关 键 词：卒中相关性肺炎 数据挖掘 中医药 配伍规律 系统聚类分析 

分 类 号：R563.1[医药卫生—呼吸系统]