植物雌激素对心血管内皮祖细胞的类雌激素保护作用的研究进展  

Estrogen-like Protective Effects of Phytoestrogens on Endothelial Progenitor Cells of Cardiovascular System

作　　者：孟园 李平 刘欣 袁晶 MENG Yuan;LI Ping;LIU Xin;YUAN Jing(Department of Cardiovascular Medicine,the Third Affiliated Hospital of Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学第三附属医院心内科,北京100029

出　　处：《医学综述》2021年第8期1457-1463,共7页Medical Recapitulate

基　　金：国家自然科学基金(81803905);北京中医药大学基本科研业务费项目(青年教师项目)(2017-JYB-JS-118);2019年北京中医药大学“青年科学家培育计划”。

摘　　要：血管内皮损伤及其功能障碍是心血管疾病(CVD)发生发展的关键环节。内皮祖细胞(EPCs)能增殖分化为内皮细胞,参与修复损伤内皮,改善内皮功能。机体自身EPCs的修复能力有限,且心血管危险因素可对EPCs产生抑制作用,进而影响内皮的修复。植物雌激素具有雌激素样作用,且作用温和,能够增强EPCs的增殖和迁移等能力,并改善内皮功能,促进损伤内皮的修复,从而延缓绝经后女性CVD的进展。因此,不断探索植物雌激素对CVD的作用机制并运用于临床,对预防和改善CVD具有重要意义。Vascular endothelial injury and dysfunction are the key factors in the occurrence and development of cardiovascular diseases(CVD).Endothelial progenitor cells(EPCs)can proliferate and differentiate into endothelial cells,repair them and improve their dysfunction.The ability of the body’s own EPCs to repair damaged endothelium is limited,and the cardiovascular risk factors may inhibit EPCs,which further affects the repair of endothelium.Phytoestrogen has mild estrogen-like effects milder effect than estrogen,which can increase the proliferation and migration of EPCs,improve endothelial function,and promote the repair of damaged endothelium,due to which it delays the progression of cardiovascular disease in postmenopausal women.Therefore continuous exploration of the mechanism of phytoestrogens on CVD and the application in clinical are important to the prevention and improvement of CVD.

关 键 词：心血管疾病 植物雌激素 内皮祖细胞 细胞保护 绝经后期 

分 类 号：R543[医药卫生—心血管疾病]