抗抑郁药物治疗双相情感障碍的研究进展  

Research progress of antidepressant therapy for bipolar disorder

作　　者：王嘉薇 尚靖[2] 陈嘉 WANG Jia-wei;SHANG Jing;CHEN Jia(Shanghai Synergy Pharmaceutical Sciences Co.,Ltd,Shanghai 201203,China;State Key Laboratory of Natural Medicines,China Pharmaceutical University Nanjing 210009,China)

机构地区：[1]上海华汇拓医药科技有限公司,上海201203 [2]中国药科大学天然药物活性组分与药效国家重点实验室,江苏南京210009

出　　处：《现代药物与临床》2021年第3期628-632,共5页Drugs & Clinic

摘　　要：双相情感障碍是一种抑郁和躁狂两极交替或混合发作的重性情感障碍,具有慢性、高复发性和高致残性,因此受到了学者的极大关注。抗抑郁药物的介入易使双相情感障碍患者从抑郁转为躁狂,其应用一直饱受质疑。因此从三环类抗抑郁药、选择性5-羟色胺再摄取抑制剂、去甲肾上腺素-多巴胺再摄取抑制剂、5-羟色胺和去甲肾上腺素再摄取抑制剂、单胺氧化酶抑制剂、褪黑激素类药药物类型方面综述多种抗抑郁药物在双相情感障碍中的疗效和安全性,阐述双相情感障碍中抗抑郁药物合理选择的重要性和必要性。Bipolar disorder is a kind of major affective disorder with alternate or mixed episodes of depression and mania.It has chronic,high recurrence and high disability,so it has attracted great attention from the researchers.The intervention of antidepressants can easily change bipolar disorder patients from depression to mania,and its application has been questioned.Therefore,the efficacy and safety of a variety of antidepressants in bipolar disorder were reviewed from the aspects of tricyclic antidepressants,selective serotonin reuptake inhibitors,norepinephrine dopamine reuptake inhibitors,serotonin and norepinephrine reuptake inhibitors,monoamine oxidase inhibitors and melatonin drugs,and the role of antidepressants in bipolar disorder was elaborated,and this article describes the importance and necessity of rational choice of antidepressants in bipolar disorder.

关 键 词：抗抑郁药物 双相情感障碍 三环类抗抑郁药 疗效 安全性 

分 类 号：R964[医药卫生—药理学]