柚皮苷对脑梗死保护作用的研究进展  

Research progress on the protective effect of naringin on cerebral infarction

作　　者：张巧莲 范宏光[2] 李平 陈静 陈旭义 ZHANG Qiao-lian;FAN Hong-guang;LI Ping;CHEN Jing;CHEN Xu-yi(Department of Neurology,Armed Police Special Medical Center,Tianjin 300163,China;Department of Neurology,Tianjin Fourth Central Hospital,Tianjin 300140,China;Research Institute of Maritime Rights Medical Support,Armed Police Special Medical Center,Tianjin 300163,China)

机构地区：[1]武警特色医学中心神经内科,天津300163 [2]天津市第四中心医院神经内科,天津300140 [3]武警特色医学中心海上维权医学保障研究所,天津300163

出　　处：《现代药物与临床》2021年第3期633-636,共4页Drugs & Clinic

基　　金：国家自然科学基金资助项目(11672332)。

摘　　要：脑梗死是多种脑血管病变引起脑部血液供应出现障碍,使脑组织缺血或者缺氧性坏死,进而引起的一系列神经功能缺损综合征。近年来我国脑梗死的发病率逐年升高,致死率、致残率均极高,严重危害人们的身心健康。临床对于脑梗死损伤的研究颇多,可能与氧化应激、炎症、钙超载、凋亡等有关。柚皮苷是一种天然黄酮类化合物,具有抗氧化应激、抗炎、减轻钙离子超载、抗细胞凋亡作用,能够对脑组织起到有效的保护作用,改善患者的预后情况。因此对柚皮苷的脑梗死保护作用的机制进行综述。Cerebral infarction is a series of neurological deficit syndromes caused by a variety of cerebrovascular diseases that cause the injured blood supply to the brain,which makes the brain tissue ischemia or hypoxic necrosis.In recent years,the cerebral infarction in our country has been increasing year by year with extremely high fatality rate and disability rate,which seriously endangers people’s physical and mental health.There have been many clinical studies on the secondary injury of cerebral infarction,which may be related to oxidative stress,inflammation,calcium overload,and apoptosis.Naringin is a natural flavonoid compound,which has the effects of anti-oxidative stress,anti-inflammatory,reducing calcium ion overload,and anti-apoptosis.Naringin can effectively protect brain tissue and improve the prognosis of patients.Therefore,the paper discusses the protective effect of naringin on cerebral infarction and its possible mechanism.

关 键 词：柚皮苷 脑梗死 保护作用 抗氧化应激 抗炎 减轻钙离子超载 抗细胞凋亡 研究进展 

分 类 号：R971[医药卫生—药品]