Micropillar-arrayed surfaces promote transforming growth factor beta 1 induced epithelial to mesenchymal transition by focal adhesion kinase-related signaling in A549 cells  

作　　者：Lun-Kun Ma Xing Wang Xiao-Li Xu Jin Zhou Yi Liao Jian-Guo Feng Li-Ling Tang 

机构地区：[1]Key Laboratory of Biorheological Science and Technology,Ministry of Education,College of Bioengineering,Chongqing University,Chongqing 400044,China [2]School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200030,China [3]Department of Thoracic Surgery,Southwest Hospital,Army Medical University(Third Military Medical University),Chongqing 400038,China [4]Department of Anesthesiology,The Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan 646099,China

出　　处：《Chinese Medical Journal》2021年第6期754-756,共3页中华医学杂志（英文版）

基　　金：Natural Science Foundation of China(Nos.31670952 and 81702921);Chongqing Graduate Scientific Research and Innovation Foundation of China(No.CYB19043);Fundamental Research Funds for the Central Universities(No.2018CQDYSG0021)。

摘　　要：To the Editor:Substrate rigidity and topography are two important biomechanical factors that can modulate the biological behavior of cancer cells such as epithelial to mesenchymal transition(EMT).Currently,although studies have begun to focus on how the mechanical microenvironment determines the fate of multiple cells,the mechanism of the mechanical microenvironment affecting EMT is still unclear.

关 键 词：transition RIGIDITY MESENCHYMAL 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]