Osseointegration of porous titanium and tantalum implants in ovariectomized rabbits:A biomechanical study  

作　　者：Stanislav Bondarenko Volodymyr Filipenko Michael Karpinsky Olena Karpinska Gennadiy Ivanov Valentyna Maltseva Ahmed Amine Badnaoui Ran Schwarzkopf 

机构地区：[1]Department of Joint Pathology,Sytenko Institute of Spine and Joint Pathology,Kharkiv 61124,Ukraine [2]Department of Biomechanics,Sytenko Institute of Spine and Joint Pathology,Kharkiv 61124,Ukraine [3]Department of Experimental Pathology,Sytenko Institute of Spine and Joint Pathology,Kharkiv 61124,Ukraine [4]Morphology of Connective Tissue Department,Sytenko Institute of Spine and Joint Pathology,Kharkiv 61124,Ukraine [5]Department of Orthopedic Surgery,NYU Langone Orthopedic Hospital,Hospital for Joint Diseases,New York,NY 10003,United States

出　　处：《World Journal of Orthopedics》2021年第4期214-222,共9页世界骨科杂志（英文版）

摘　　要：BACKGROUND Today,biological fixation of uncemented press-fit acetabular components plays an important role in total hip arthroplasty.Long-term stable fixation of these implants depends on the osseointegration of the acetabular cup bone tissue into the acetabular cup implant,and their ability to withstand functional loads.AIM To compare the strength of bone-implant osseointegration of four types of porous metal implants in normal and osteoporotic bone in rabbits.METHODS The study was performed in 50 female California rabbits divided into nonovariectomized(non-OVX)and ovariectomized groups(OVX)at 6 mo of age.Rabbits were sacrificed 8 wk after the implantation of four biomaterials[TTM,CONCELOC,Zimmer Biomet's Trabecular Metal(TANTALUM),and ATLANT]in a 5-mm diameter defect created in the left femur.A biomechanical evaluation of the femur was carried out by testing implant breakout force.The force was gradually increased until complete detachment of the implant from the bone occurred.RESULTS The breakout force needed for implant detachment was significantly higher in the non-OVX group,compared with the OVX group for all implants(TANTALUM,194.7±6.1 N vs 181.3±2.8 N;P=0.005;CONCELOC,190.8±3.6 N vs 180.9±6.6 N;P=0.019;TTM,186.3±1.8 N vs 172.0 N±11.0 N;P=0.043;and ATLANT,104.9±7.0 N vs 78.9 N±4.5 N;P=0.001).In the OVX group,The breakout forces in TANTALUM,TTM,and CONCELOC did not differ significantly(P=0.066).The breakout force for ATLANT in the OVX group was lower by a factor of 2.3 compared with TANTALUM and CONCELOC,and by 2.2 compared with TTM(P=0.001).In the non-OVX group,the breakout force for ATLANT was significantly different from all other implants,with a reduction in fixation strength by a factor of 1.9(P=0.001).CONCLUSION TANTALUM,TTM,and CONCELOC had equal bone-implant osseointegration in healthy and in osteoporotic bone.ATLANT had significantly decreased osseointegration(P=0.001)in healthy and in osteoporotic bone.

关 键 词：Animals Bone-implant interface Osteoporosis FEMUR TANTALUM Titanium 

分 类 号：R687.4[医药卫生—骨科学]