姜黄素纳米混悬剂的制备及体外释放研究  

Optimized the Formulation of Curcumin Nanosuspension by Box-Behnken Design-Response Surface Methodology

作　　者：高春玲 张昕宁 王岩松 华宇轩 李朋菲 暴大林 孙维彤[1] GAO Chunling;ZHANG Xinning;WANG Yansong;HUA Yuxuan;LI Penfei;BAO Dalin;SUN Weitong(College of Pharmacy of Jiamusi University, Jiamusi Heilongjiang 154007,China)

机构地区：[1]佳木斯大学药学院,黑龙江佳木斯154007

出　　处：《佳木斯大学学报（自然科学版）》2021年第2期114-117,共4页Journal of Jiamusi University：Natural Science Edition

基　　金：黑龙江省省属高等学校基本科研业务费项目(2019-KYYWF-1342);佳木斯大学博士专项科研基金启动项目(JMSUBZ2019-14);国家大学生创新创业训练项目(201910222019);黑龙江省北药与功能食品特色学科建设项目(2018-TSXK-02)。

摘　　要：制备姜黄素纳米混悬剂,并对其体外释放行为进行研究。方法采用溶剂沉淀法制备姜黄素纳米混悬剂;以纳米混悬剂的粒径大小、多分散系数(PDI)和Zeta电位为指标,通过单因素试验设计优化处方及制备工艺;利用差示扫描量热法对其形态表征;使用桨法考察其体外释放行为。结果制备的纳米混悬剂平均粒径为(159.6±2.95)nm,PDI为0.175±0.014,Zeta电位为-24.3±0.23,平均载药量为(16.5±0.04)%,平均包封率为(95.3±0.02)%;姜黄素以无定形存在;30 min时纳米混悬液累积溶出达(97.4±3.46)%,纳米混悬剂能显著提高药物的体外溶出度。结论姜黄素纳米混悬剂制备方法简单易行,稳定性良好,为改善姜黄素溶解性差问题提供了一种方法,具有较好的应用前景。OBJECTIVE To prepare the curcumin nanosuspension(CUR-NS)and investigate dissolution behaviors in vitro.METHODS CUR-NS was prepared using the precipitation method.The particle size,PDI and Zeta potential were conducted quality evaluation,the prescription and preparation process of CUR-NS were optimized by the single factor.The morphology was observed by differential scanning calorimetry(DSC).Paddle method was used to study dissolution of CUR-NS in vitro.RESULTS The average particle size was(159.6±2.95)nm,PDI was 0.175±0.014,Zeta potential was-24.3±0.23,average entrapment rate was(95.3±0.02)%,average drug loading rate was(16.5±0.04)%,the curcumin was in the form of amorphous,the cumulative dissolution of CUR-NS was(97.4±3.46)%at 30 min,the dissolution rate of curcumin was significantly improved by nanosuspension technology.CONCLUSION The preparation method of CUR-NS with good stability is simple.CUR-NS solved the problem of poor water solubility of CUR-NS and had a good application prospect.

关 键 词：姜黄素 沉淀法 纳米混悬剂 体外释放 

分 类 号：R943[医药卫生—药剂学]