布地奈德联合特布他林治疗AECOPD  

Budesonide combined with terbutaline in the treatment of AECOPD

作　　者：别福鑫 王迪[1] 吕玉凤[1] 姜爱英[1] 赵丽丽[1] 张丽[1] BIE Fu-xin(Mudanjiang Medical University, Mudanjiang 157011, China)

机构地区：[1]牡丹江医学院,黑龙江牡丹江157011

出　　处：《牡丹江医学院学报》2021年第2期67-70,共4页Journal of Mudanjiang Medical University

基　　金：国家社科基金青年项目(17CRK015);山西省高等学校科技创新项目(2020L0403;2019L0669)。

摘　　要：目的探究不同剂量布地奈德联用特布他林对治疗慢性阻塞性肺疾病急性加重期(acute exacerbations of Chronic Obstructive Lung Disease,AECOPD)患者的治疗效果和副反应。方法选择2017年9月至2018年9月间红旗医院呼吸内科确诊的90例中重度AECOPD患者并随机分为3组,每组30人,对照组给予雾化吸入特布他林雾化液5 mg,试验1组给予特布他林雾化液5 mg+布地奈德混悬液1 mg,试验2组给予特布他林雾化液5 mg+布地奈德混悬液2 mg,观察治疗前、治疗14 d后三组患者的肺功能、血气分析的改变。结果用药前三组肺功能比较无差异(P=0.26),用药后试验1组、2组肺功能指标FEV1%及FEV1/FVC较治疗前均提高,试验2组比试验1组肺功能指标提高更显著(P<0.05);用药前三组患者比较PaO2、PaCO2均无差别,用药后三组比较PaO2、PaCO2均有差别,试验2组PaO2高于试验1组高于对照组,试验2组PaCO2低于试验1组低于对照组(P<0.05)。结论雾化吸入布地奈德(4 mg/d)联用特布他林较应用布地奈德(2 mg/d)联用特布他林对AECOPD患者肺功能、血气分析改善更显著,同时无明显不良反应,值得临床推广。Objective To explore the therapeutic and side effects of different doses of budesonide combined with terbutaline in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease. Methods Patients with AECOPD diagnosed in the Department of Respiratory Medicine of Hongqi Hospital from September 2017 to September 2018 were selected and randomly divided into 3 groups and each group of 30 people. Control group was given atomized inhalation of terbutaline atomization solution 5 mg, test group 1 was given terbutaline atomization solution 5 mg and budesonide suspension 1 mg, and test group 2 was given terbutaline atomization solution 5 mg and budesonide suspension 2 mg. The changes of lung function and blood gas analysis of the three groups of patients were observed before and after 14 days of treatment. Results There was no difference in lung function between the three groups before medication(P=0.26), After treatment, FEV1% and FEV1/FVC of lung function indexes in test groups 1 and 2 were increased compared with those before treatment, and the improvement of lung function indexes in test group 2 was more significant than that in test group 1(P<0.05);There were no differences in PaO2 and PaCO2 among the three groups before medication, but there were differences in PaO2 and PaCO2 among the three groups after medication. PaO2 in test group 2 was higher than that in test group 1 and higher than that in control group, and PaCO2 in test group 2 was lower than that in test group 1 and lower than that in control group(P<0.05). Conclusion Atomized inhalation of budesonide(4 mg/d) combined with terbutaline improved lung function and blood gas analysis more significantly than budesonide(2 mg/d) combined with terbutaline in patients with AECOPD, with no obvious adverse reactions, which is worthy of clinical promotion.

关 键 词：临床疗效 AECOPD 布地奈德 特布他林 

分 类 号：R563.9[医药卫生—呼吸系统]