脂蛋白磷脂酶A2、非高密度胆固醇与颈动脉粥样硬化程度的相关性研究  

Study on the Correlation Between Lipoprotein Phospholipase A2,Non-high-density Cholesterol and the Degree of Carotid Atherosclerosis

作　　者：来佳成 韩永生 LAI Jia-cheng;HAN Yong-sheng(Emergency Medicine Center,Provincial Hospital Affiliated to Anhui Medical University,Hefei 230001,Anhui,China)

机构地区：[1]安徽医科大学附属省立医院急救医学中心,安徽合肥230001

出　　处：《医学信息》2021年第9期115-118,共4页Journal of Medical Information

基　　金：安徽省重点研究与开发计划项目(编号:1804h08020291);安徽省科技重大专项(编号:201903a07020027)。

摘　　要：目的研究脂蛋白磷脂酶A2、非高密度脂蛋白胆固醇与颈动脉粥样硬化程度的关系,探索Lp-PLA2联合non-HDL-C预测颈动脉粥样硬化程度的应用价值。方法回顾性分析2019年10月~2020年4月就诊于中国科学技术大学附属第一医院急救中心,并同时行Lp-PLA2检测和颈动脉评估的患者226例临床资料,根据颈动脉评估情况分为对照组(n=58)、轻度病变组(n=118)、重度病变组(n=50),比较各组一般资料、Lp-PLA2、non-HDL-C水平,分析Lp-PLA2与non-HDL-C的相关性。结果病变组与对照组糖尿病、高同型半胱氨酸、肾功能不全占比比较,差异有统计学意义(P<0.05),轻度病变组与重度病变组比较,差异无统计学意义(P>0.05);三组间Lp-PLA2、non-HDL-C、斑块计数两两比较,差异有统计学意义(P<0.05);线性相关分析结果显示,Lp-PLA2与non-HDL-C呈线性相关(r=0.465,P<0.001)。结论Lp-PLA2、non-HDL-C与颈动脉粥样硬化程度显著相关,提示两者可用于颈动脉动脉粥样硬化程度的预测,进一步提升评价效果的可靠性。Objective To study the relationship between lipoprotein phospholipase A2,non-high-density lipoprotein cholesterol and the degree of carotid atherosclerosis,and explore the application value of Lp-PLA2 combined with non-HDL-C in predicting the degree of carotid atherosclerosis.Methods A retrospective analysis of the clinical data of 226 patients in the emergency center of the First Affiliated Hospital of the USTC from October 2019 to April 2020,and who underwent Lp-PLA2 detection and carotid artery assessment,were retrospectively analyzed.According to the assessment of carotid artery,they were divided into control group(n=58),mild disease group(n=118),and severe disease group(n=50).The general data,Lp-PLA2,non-HDL-C levels of each group were compared,and the correlation between Lp-PLA2 and non-HDL-C was analyzed.Results There was a statistically significant difference in the proportion of diabetes,high homocysteine,and renal insufficiency between the diseased group and the control group(P<0.05).There was no statistically significant difference between the mild disease group and the severe disease group(P>0.05);Pairwise comparisons of Lp-PLA2,non-HDL-C,and plaque counts among the three groups showed statistically significant differences(P<0.05);The results of linear correlation analysis showed that Lp-PLA2 was linearly correlated with non-HDL-C(r=0.465,P<0.001).Conclusion Lp-PLA2 and non-HDL-C are significantly related to the degree of carotid atherosclerosis,suggesting that both can be used to predict the degree of carotid atherosclerosis,and further improve the reliability of the evaluation effect.

关 键 词：脂蛋白磷脂酶A2 非高密度脂蛋白胆固醇 颈动脉粥样硬化 

分 类 号：R543.4[医药卫生—心血管疾病]