百日咳外膜囊泡的研究进展及其作为新型替代疫苗的可能性  

Research progress in Bordetella pertussis outer membrane vesicles and their potential usage as an novel alternative vaccine

作　　者：刘兆禄 潘超(综述) 朱力 王恒樑(审校)[1,2] LIU Zhao-lu;PAN Chao;ZHU Li;WANG Heng-liang(College of Food Science and Technology,Shanghai Ocean University,Shanghai 201306,China;不详)

机构地区：[1]上海海洋大学食品学院,上海201306 [2]军事医学研究院生物工程研究所,北京100071

出　　处：《中国生物制品学杂志》2021年第3期367-371,共5页Chinese Journal of Biologicals

基　　金：国家自然科学基金(31700802)。

摘　　要：百日咳由百日咳博德特菌感染引起,是一种具有高度传染性的呼吸道疾病,婴儿和儿童是发病的高危人群。目前,全球百日咳疫苗有全细胞疫苗(whole-cell pertussis vaccine,wP)和无细胞疫苗(acellular pertussis vaccine,aP)两种,虽然接种覆盖率较高,但控制效果不佳,百日咳仍是儿童死亡的主要病因之一。百日咳博德特菌的外膜囊泡(outer membrane vesicles,OMVs)是该菌表面分泌的一种具有球形双层膜、天然非复制性的囊泡结构,可诱导出较强的免疫应答,产生长期保护作用。因此,本文对百日咳OMVs的研究进展及其作为新型替代疫苗的可能性作一综述。Pertussis is a highly contagious respiratory disease caused by Bordetella pertussis infection,with a high risk of morbidity in infants and children. Despite the high global vaccination coverage of whole cell and acellular pertussis vaccines,pertussis is still a major cause od death in children. Neither of the two vaccines available has satisfactory preventive effect on pertussis. Outer membrane vesicles(OMVs)are natural non-replicable vesicles with spherical bilayer membrane,which may induce strong immune response and persistent protection. This article reviews the research status of OMVs of Bordetella pertussis and their potential usage as a novel alternative vaccine..

关 键 词：百日咳博德特菌 外膜囊泡 抗原载体 疫苗 

分 类 号：R378[医药卫生—病原生物学]