基础胰岛素治疗的2型糖尿病患者进行餐后行走与增加餐前胰岛素治疗的对比研究  

A comparative study of the efficacy of walking after a meal and increasing pre-meal insulin therapy in patients with type 2 diabetes treated with basal insulin

作　　者：谭萨萨[1] 冯宪真[2] 周军[2] 丁晶晶 沈啸翼[2] Tan Sasa;Feng Xianzhen;Zhou Jun;Ding Jingjing;Shen Xiaoyi(Department of Endocrinology,Tongren Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200336,China;不详)

机构地区：[1]上海交通大学医学院附属同仁医院内分泌内科,上海200336 [2]上海交通大学医学院附属同仁医院全科医疗科,上海200336

出　　处：《中国临床保健杂志》2021年第2期225-228,共4页Chinese Journal of Clinical Healthcare

基　　金：上海市长宁区医学名专科-全科医学科项目(YXMZK009)。

摘　　要：目的评估餐后行走与餐前加强胰岛素注射对基础胰岛素治疗的2型糖尿病的影响。方法对接受基础胰岛素治疗的2型糖尿病患者进行了餐后行走或餐前加强胰岛素注射的随机对照研究。在餐后行走组中,患者每天晚饭后行走15~20 min,持续10周。在餐前加强胰岛素组中,早餐或主餐前使用短效胰岛素进行加强注射。结果32名患者完成了本次研究。餐后步行组(17例)和加强胰岛素注射组(15例)的糖化血红蛋白(HbA1c)分别降低了0.05(范围:-1.08~0.74)和0.19(范围:-0.8~0.56)。但是,各组之间的HbA1c水平降低差异无统计学意义。饭后行走组在第5周和第10周,糖化血清白蛋白水平分别降低了17.5μmol/L(-59~43μmol/L)和10μmol/L(-15~40μmol/L),而加强胰岛素注射组的相应变化分别为12.5μmol/L(-17~64μmol/L)和17.5μmol/L(-28~38μmol/L),各组之间的糖化血清白蛋白减少量与基线相比差异均无统计学意义。结论餐后行走对改善基础胰岛素治疗的2型糖尿病患者的血糖可能与餐前加强胰岛素注射一样有效。Objective To evaluate the effect of walking after meals compared with pre-meal booster insulin injections on type 2 diabetes treated with basal insulin.Methods Randomized controlled study was conducted among the patients with type 2 diabetes who received basal insulin therapy for walking after a meal or boosting insulin injections.In the group of walking after meals,patients walked for 15 to 20 minutes after dinner every day for 10 weeks.In the pre-meal booster insulin group,short-acting insulin was used for booster injection before breakfast or main meal.Results 32 patients completed the study.The HbA1c of the walking group and the booster insulin injection group decreased 0.05(range:-1.08 to 0.74)and 0.19(range:-0.8 to 0.56)respectively.However,the HbA1c reduction in each group and between groups was not significantly different from the baseline.In the group of walking after meals,fructosamine levels were reduced by 17.5(-59 to 43)and 10(-15 to 40)μmol/L in the 5rd and 10th weeks,respectively,while the corresponding changes in the booster insulin injection group were 12.5(-17 to 64)and 17.5(-28 to 38)μmol/L.There was no significant difference in the reduction of fructosamine in each group and between groups compared with baseline.Conclusion Although walking after a meal may be as effective in improving the blood glucose of type 2 diabetic patients treated with basic insulin as the pre-meal booster insulin injection.

关 键 词：糖尿病 2型 胰岛素 步行 饭后期间 运动 

分 类 号：R58[医药卫生—内分泌]