Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles  

作　　者：Justus Amuche Nweze Florence N.Mbaoji Yan-Ming Li Li-Yan Yang Shu-Shi Huang Vincent N.Chigor Emmanuel A.Eze Li-Xia Pan Ting Zhang Deng-Feng Yang 

机构地区：[1]Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry,National Engineering Research Center of Non-Food Biorefi nery,State Key Laboratory of Non-Food Biomass and Enzyme Technology,Guangxi Academy of Sciences,Nanning 530007,Guangxi,People's Republic of China [2]Nation al Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention,WHO Collaborating Center for Tropical Diseases,Natio nal Center for Inter national Research on Tropical Diseases,Key Laboratory of Parasite and Vector Biology of the Chinese Ministry of Health,Shanghai 200025,People's Republic of China Full list of author information is available at the end of the article

出　　处：《Infectious Diseases of Poverty》2021年第1期95-96,共2页贫困所致传染病（英文）

摘　　要：Background:Malaria and neglected communicable protozoa parasitic diseases,such as leishmaniasis,and trypanosomiasis,are among the otherwise called diseases for neglected communities,which are habitual in underprivileged populations in developing tropical and subtropical regions of Africa,Asia,and the Americas.Some of the currently available therapeutic drugs have some limitations such as toxicity and questionable efficacy and long treatment period,which have encouraged resistance.These have prompted many researchers to focus on fin ding new drugs that are safe,effective,and affordable from marine environ merits.The aim of this review was to show the diversity,structural scaffolds,in-vitro or in-vivo efficacy,and recent progress made in the discovery/isolation of marine natural products(MNPs)with potent bioactivity against malaria,leishmaniasis,and trypanosomiasis.Main text:We searched PubMed and Google scholar using Boolean Operators(AND,OR,and NOT)and the combination of related terms for articles on marine natural products(MNPs)discovery published only in English language from January 2016 to June 2020.Twenty nine articles reported the isolation,identification and antiparasitic activity of the isolated compounds from marine environment.A total of 125 compounds were reported to have been isolated,out of which 45 were newly isolated compounds.These compounds were all isolated from bacteria,a fungus,sponges,algae,a bryozoan,cnidarians and soft corals.In recent years,great progress is being made on anti-malarial drug discovery from marine organisms with the isolation of these potent compounds.Comparably,some of these promising antikinetoplastid MNPs have potency better or similar to conventional drugs and could be developed as both antileishmanial and antitrypanosomal drugs.However,very few of these MNPs have a pharmaceutical destiny due to lack of the following:sustainable production of the bioactive compounds,stan da rd efficient screening methods,knowledge of the mechanism of action,partnerships between researche

关 键 词：Marine natural products Neglected tropical diseases Anti-trypanosoma Anti-leishmania Anti-plasmodia Protozoa parasites 

分 类 号：R531.3[医药卫生—内科学] R181.3[医药卫生—临床医学]