补肾调经汤对多囊卵巢综合征伴胰岛素抵抗肾虚痰阻证患者糖脂代谢和子宫内膜容受性的影响  

Effect of Bushen Tiaojing Decoction on glucose and lipid metabolism and endometrial receptivity in patients with polycystic ovary syndrome with insulin resistance of syndrome of kidney deficiency and phlegm obstruction

作　　者：赵维青 李长忠[2] ZHAO Weiqing;LI Changzhong(Shandong University of Traditional Chinese Medicine, Jinan 250013, Shandong, China;Shandong Provincial Hospital, Jinan 250021, Shandong, China)

机构地区：[1]山东中医药大学,山东济南250013 [2]山东省立医院,山东济南250021

出　　处：《现代中西医结合杂志》2021年第14期1526-1530,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察自拟补肾调经汤对多囊卵巢综合征伴胰岛素抵抗肾虚痰阻证患者糖脂代谢和子宫内膜容受性的影响。方法将2018年1月—2019年2月山东省立医院收治的90例多囊卵巢综合征伴胰岛素抵抗肾虚痰阻证患者随机分为2组,对照组给予屈螺酮炔雌醇片、盐酸二甲双胍片口服,血脂异常者给予普伐他汀钠片口服,观察组在对照组治疗基础上给予补肾调经汤治疗,2组均连续治疗3个月经周期,对比2组治疗前后糖代谢指标[空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)]、脂代谢指标[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、子宫内膜容受性(子宫内膜厚度、子宫螺旋动脉搏动指数、子宫螺旋动脉阻力指数),评估2组临床疗效及不良反应发生情况。结果与治疗前比较,2组治疗后FPG、FINS、HOMA-IR、TC、TG、LDL-C水平及子宫螺旋动脉搏动指数、子宫螺旋动脉阻力指数均明显降低(P均<0.05),且观察组均明显低于对照组(P均<0.05);与治疗前比较,2组治疗后HDL-C、子宫内膜厚度均明显升高(P均<0.05),且观察组均明显高于对照组(P均<0.05)。观察组治疗总有效率为91.1%(41/45),明显高于对照组的71.1%(32/45),差异有统计学意义(χ^(2)=5.874,P<0.05);2组治疗期间均未发生严重不良反应。结论补肾调经汤联合西药治疗多囊卵巢综合征伴胰岛素抵抗肾虚痰阻证患者效果更好,能够有效调节糖、脂代谢,改善子宫内膜容受性,且安全。Objective It is to observe the effect of self-made Bushen Tiaojing Decoction on glucose and lipid metabolism and endometrial receptivity in patients with polycystic ovary syndrome with insulin resistance of syndrome of kidney deficiency and phlegm obstruction.Methods Ninety patients with polycystic ovary syndrome with insulin resistance of syndrome of kidney deficiency and phlegm obstruction treated in Shandong Provincial Hospital from January 2018 to February 2019 were randomly divided into 2 groups.The control group was treated with drospirenone and ethinyl estradiol tablets and hydrochloric metformin tablets,the patients with abnormal blood lipids were given pravastatin sodium tablets.The observation group was treated with Bushen Tiaojing Decoction on the basis of the treatment of the control group.Both groups were treated for 3 consecutive menstrual cycles.The glucose metabolism indexes[fasting blood glucose(FPG),fasting insulin(FINS),insulin resistance index(HOMA-IR)],lipid metabolism indicators[total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density Lipoprotein cholesterol(HDL-C)],endometrial receptivity(endometrial thickness,uterine spiral artery pulsatility index,uterine spiral artery resistance index)before and after treatment were compared in the two groups,the clinical efficacy and adverse reactions in the two groups were evaluated.Results Compared with before treatment,the levels of FPG,FINS,HOMA-IR,TC,TG,LDL-C,uterine spiral artery pulsatility index and uterine spiral artery resistance index were significantly reduced after treatment in the two groups(all P<0.05),and the observation group was significantly lower than the control group(P<0.05);the HDL-C and endometrial thickness of the two groups were significantly increased after treatment(all P<0.05),and the observation group was significantly higher than the control group(all P<0.05).The total effective rate of treatment in the observation group was 91.1%(41/45),which was significantly higher than 71.1%(32/45

关 键 词：多囊卵巢综合征 胰岛素抵抗 肾虚痰阻型 补肾调经汤 糖脂代谢 子宫内膜容受性 

分 类 号：R711.75[医药卫生—妇产科学]