盐酸氨溴索联合利奈唑胺治疗重症肺炎患者的临床疗效及对血气指标的影响分析  

Effects of Ambroxol Hydrochloride Combined with Linezolid on Clinical Curative Effect and Blood Gas Indexes in Patients with Severe Pneumonia

作　　者：任芳[1] 郝同琴[1] 牛丽丹[1] 张江波 Ren Fang;Hao Tongqin;Niu Lidan;Zhang Jiangbo(Department of Emergency of the First Affiliated Hospital of Xinjriang Medical College,Xinxiang 453000,China)

机构地区：[1]新乡医学院第一附属医院急诊科,新乡453000

出　　处：《四川解剖学杂志》2021年第1期9-11,共3页Sichuan Journal of Anatomy

摘　　要：目的探讨盐酸氨溴索联合利奈唑胺治疗重症肺炎患者的临床疗效及对血气指标的影响。方法选取2019年2月~2020年1月于我院住院治疗的116例重症肺炎患者作为研究对象,采用随机数字表法分为观察组和对照组,每组各58例。其中对照组采用利奈唑胺治疗,观察组在对照组治疗基础上加用盐酸氨溴索液治疗,均治疗7d。治疗后比较两组患者总有效率,以及治疗前、后的炎性细胞因子水平、血气指标。结果治疗后,观察组患者的治疗总有效率明显高于对照组(P<0.05);观察组患者血清TNF-α、PCT、HMGB1、IL-1β水平和PaCO_(2)均明显低于对照组(P<0.05),PaO_(2)、SaO_(2)均明显高于对照组(P<0.05)。结论采用盐酸氨溴索联合利奈唑胺治疗重症肺炎患者可明显改善血气指标,降低机体炎性细胞因子水平,具有较好的临床疗效。Objective This study aimed to explore the effects of ambroxol hydrochloride combined with linezolid on clinical curative effect and blood gas indexes in patients with severe pneumonia. Methods A total of 116 patients with severe pneumonia admitted to our hospital from February 2019 to January 2020 were enrolled as the research objects. They were randomly divided into observation group(n=58) and control group(n=58) with a random number table by using block randomization. The control group was treated with linezolid, while observation group was treated with ambroxol hydrochloride and linezolid. All patients were treated for 7 d. The total response rate after treatment were evaluated, inflammatory cytokines [TNF-α,, HMGB1, IL-1β] and blood gas indexes [PaO_(2), PaCO_(2), SaO_(2)] was recorded before and after treatment, and incidence of adverse reactions during treatment were compared between the two groups. Results After treatment, the total response rate of treatment in observation group was significantly higher than that in control group(P<0.05). The disappearance time of fever, cough, expectoration and lung rales, and negative conversion time of sputum bacteria in observation group were shorter than those in control group(P<0.05). The levels of serum TNF-α,, HMGB1 and IL-1β, and PaCO_(2) in observation group were lower than those in control group(P<0.05), while PaO_(2) and SaO_(2) were higher than those in control group(P<0.05).Conclusion The application of ambroxol hydrochloride combined with linezolid in the treatment of patients with severe pneumonia can significantly improve blood gas indexes, reduce levels of inflammatory cytokines, with good clinical curative effects.

关 键 词：盐酸氨溴索 利奈唑胺 重症肺炎 血气指标 疗效 

分 类 号：R563.1[医药卫生—呼吸系统]