多模板分子印迹固相萃取及其在中药多组分提取分离中的应用  

Multi-template molecularly imprinted solid phase extraction and its application in the extraction and separation of multi-components from traditional Chinese medicine

作　　者：李硕 常月月 程芳芳[1] 包贝华[1] 曹雨诞[1] 姚卫峰[1] 张丽[1] 丁安伟[1] LI Shuo;CHANG Yue-yue;CHENG Fang-fang;BAO Bei-hua;CAO Yu-dan;YAO Wei-feng;ZHANG Li;DING An-wei(School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学药学院,江苏南京210023

出　　处：《药学学报》2021年第3期751-760,共10页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金面上资助项目(81973445)。

摘　　要：多模板分子印迹固相萃取不仅具有高选择性、吸附容量大、容易制备、可重复使用以及环境污染小等优点,而且可以实现对多种化合物的富集分离,在中药成分提取分离方面受到广泛的关注。本研究总结归纳了多模板分子印迹固相萃取的最新发展,同时基于中药活性成分的种类(黄酮、生物碱、苯丙素和萜类等)分类综述多模板分子印迹固相萃取在中药多组分分离提取方面的最新应用,以期为多模板分子印迹聚合物更好应用于中药活性多组分提取分离,为中药药效物质基础研究提供参考。Multi-template molecularly imprinted solid phase extraction not only has the advantages of high selectivity, large adsorption capacity, easy preparation, reuse and low environmental pollution, but also can realize the enrichment and separation of many kinds of compounds. It has attracted wide attention in the extraction and separation of traditional Chinese medicine components. This study summarizes the latest development of multitemplate molecularly imprinted solid phase extraction. At the same time, based on the classification of active components of traditional Chinese medicine(flavonoids, alkaloids, phenylpropanol, terpenes, etc.), the latest application of multi-template molecular imprinting solid phase extraction in multi-component separation of traditional Chinese medicine was reviewed, with a view to better application of multi-template molecularly imprinted polymer in active multi-component extraction and separation of traditional Chinese medicine and provide reference for the material basic research of the efficacy of traditional Chinese medicine.

关 键 词：多模板 分子印迹 固相萃取 中药多组分 提取分离 

分 类 号：R943[医药卫生—药剂学]