没药中一个新的杜松烷型倍半萜  

A new cadinane-type sesquiterpenoid from Commiphora myrrha

作　　者：王超超 夏晖 梁乃允 王嵘晔 王鑫玉 姚会娜 霍会霞 屠鹏飞[1] 李军[1] WANG Chao-chao;XIA Hui;LIANG Nai-yun;WANG Rong-ye;WANG Xin-yu;YAO Hui-na;HUO Hui-xia;TU Peng-fei;LI Jun(Modern Research Center for Traditional Chinese Medicine,School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学中药学院中药现代研究中心,北京100029

出　　处：《药学学报》2021年第3期831-834,共4页Acta Pharmaceutica Sinica

基　　金：国家重点研发计划“中医药现代化研究”重点专项资助项目(2019YFC1711000,2018YFC1707300)。

摘　　要：采用硅胶、ODS及半制备型HPLC等色谱分离技术,对没药正己烷提取物化学成分进行系统的分离纯化,结合其理化性质、波谱数据(UV、IR、MS、NMR)和X-ray单晶衍射实验鉴定化合物的结构。从没药正己烷提取物中分离鉴定了5个杜松烷型倍半萜类化合物,分别鉴定为(3S,4R)-3,9-二甲氧基没药酮(1)、9-甲氧基没药酮(2)、没药酮(3)、commiterpene B(4)和comosoneⅡ(5)。其中化合物1为新化合物,通过X-ray单晶衍射实验确定了其绝对构型。化合物5为首次从该属植物中分离得到。Five cadinane-type sesquiterpenoids were isolated from the n-hexane extract of Commiphora myrrha by using various chromatographic techniques,including silica gel,ODS and semi-preparative HPLC.Their structures were identified by physicochemical properties and spectroscopic data.These compounds were defined as(3 S,4 R)-3,9-dimethoxymyrrhone(1),9-methoxymyrrhone(2),myrrhone(3),commiterpene B(4)and comosoneⅡ(5).Compound 1 is a new compound,of which the absolute configuration was established by single crystal X-ray crystallographic analysis.Compound 5 is firstly isolated from the Commiphora genus.

关 键 词：没药 橄榄科 没药属 杜松烷型倍半萜 

分 类 号：R284[医药卫生—中药学]