甘油三酯、空腹血糖及甘油三酯葡萄糖乘积指数与高血压发病风险的前瞻性队列研究  

Prospective cohort study of relationship of triglyceride,fasting blood-glucose and triglyceride glucose product index with risk of hypertension

作　　者：王若楠 张德生 白朝 尹春 张瑞 杨景丽 包凯芳 黄文雅 黄佩瑶 柳念 王玉峰 程宁[3] 白亚娜[1] Wang Ruonan;Zhang Desheng;Bai Zhao;Yin Chun;Zhang Rui;Yang Jingli;Bao Kaifang;Huang Wenya;Huang Peiyao;Liu Nian;Wang Yufeng;Cheng Ning;Bai Yana(Institute of Epidemiology and Health Statistics,School of Public Health,Lanzhou University,Lanzhou 730000,China;Workers'Hospital of Jinchuan Group,Jinchang 737100,China;School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学公共卫生学院流行病与卫生统计学研究所,730000 [2]金川集团职工医院,金昌737100 [3]兰州大学基础医学院,730000

出　　处：《中华流行病学杂志》2021年第3期482-487,共6页Chinese Journal of Epidemiology

基　　金：兰州大学“一带一路”专项(2018ldbrzd008);美国国立卫生研究院(1R01ES029082)。

摘　　要：目的探讨TG、FPG及TG葡萄糖乘积指数(TyG)与高血压发病间的关系,为人群高血压的防治提供基础数据。方法以金昌队列中符合研究标准的23581人作为研究对象,运用Cox比例风险模型研究TG、FPG及TyG与高血压发病风险间的关系,并按性别进行分层分析。结果在调整混杂因素后,与正常TG组相比,总人群中TG边缘升高组和升高组的HR值(95%CI)分别为1.16(1.01~1.34)和1.49(1.30~1.70),男性中分别为1.13(1.01~1.27)和1.17(1.06~1.30),女性中分别为1.05(0.88~1.26)和1.06(0.88~1.28);与正常FPG组相比,总人群中空腹血糖受损组的HR值(95%CI)为1.29(1.13~1.48),男性中为1.26(1.08~1.48),女性中为1.59(1.14~2.21);以最低四分位数组为参照,总人群中TyG的最高四分位数组的HR值(95%CI)为1.73(1.45~2.07),男性中为1.32(1.14~1.53),女性中为1.87(1.37~2.54)。TG、FPG与高血压发病风险间呈非线性的剂量反应关系,TyG与高血压发病风险线性相关。结论较高的TG、FPG、TyG是高血压发病的独立危险因素,TG、FPG及TyG较高的人群为高血压的高危人群,在高血压防治中应予以重视。Objective To investigate the relationship of triglyceride(TG),fasting blood glucose(FPG)and triglyceride glucose product index(TyG)with the incidence of hypertension,and provide basic data for the prevention and treatment of hypertension in the population.Methods A total of 23581 individuals who met the research criteria in Jinchang cohort were selected as the research subjects,the Cox proportional hazard model was used to analyze the relationship of TG,FPG,and TyG with the risk of hypertension.A stratified analysis was conducted by sex.Results After adjusting for confounding factors,compared with the normal TG group,the HR(95%CI)of the elevated TG margin group and the elevated group were 1.16(1.01-1.34)and 1.49(1.30-1.70),respectively in the total population.Among men,they were 1.13(1.01-1.27)and 1.17(1.06-1.30),and among women,they were 1.05(0.88-1.26)and 1.06(0.88-1.28).Compared with the normal FPG group,the HR(95%CI)of the FPG-impaired group were 1.29(1.13-1.48)in the total population,1.26(1.08-1.48)in men and 1.59(1.14-2.21)in women.Taking the lowest quartile array as a reference,the HR(95%CI)of the highest quartile array of TyG was 1.73(1.45-2.07)in the total population,1.32(1.14-1.53)in men and 1.87(1.37-2.54)in women.TG,FPG had a nonlinear dose-response relationship with the risk of hypertension,while TyG had a linear correlation with the risk of hypertension.Conclusions Higher TG,FPG,and TyG levels are independent risk factors for the incidence of hypertension.People with higher TG,FPG and TyG are at high risk for hypertension,to which close attention should be paid in the prevention and treatment of hypertension.

关 键 词：高血压 甘油三酯 空腹血糖 甘油三酯葡萄糖乘积指数 

分 类 号：R544.1[医药卫生—心血管疾病]