TG/HDL-C比值与冠心病患者致病风险的关系及诊断价值  

Relationship between TG/HDL-C ratio and the risk of coronary heart disease and its diagnostic value

作　　者：杨林[1] 葛百平 姜珊[3] 付强[1] 刘文书 赵林林[4] YANG Lin;GE Baiping;JIANG Shan;FU Qiang;LIU Wenshu;ZHAO Linlin(Department of Internal Medicine-Cardiovascular,the People’s Hospital of Liaoning Province,Liaoning Province,Shenyang110016,China;Department of Emergency,the People’s Hospital of Liaoning Province,Liaoning Province,Shenyang110016,China;Department of Respiratory,Shengjing Hospital Affiliated to China Medical University,Liaoning Province,Shenyang110000,China;Department of Cardiac Surgery,the People’s Hospital of Liaoning Province,Liaoning Province,Shenyang110016,China)

机构地区：[1]辽宁省人民医院心内科,辽宁沈阳110016 [2]辽宁省人民医院急诊科,辽宁沈阳110016 [3]中国医科大学附属盛京医院呼吸科,辽宁沈阳110000 [4]辽宁省人民医院心外科,辽宁沈阳110016

出　　处：《中国医药导报》2021年第11期66-69,共4页China Medical Herald

基　　金：辽宁省自然科学基金指导计划项目(2019-ZD-0417)。

摘　　要：目的探讨三酰甘油/高密度脂蛋白胆固醇(TG/HDL-C)比值与冠心病(CHD)患者致病风险的关系及诊断价值。方法选取2017年6月—2019年6月于辽宁省人民医院就诊的CHD患者100例(CHD组)及非CHD患者(非CHD组)100例作为研究对象。比较两组TG/HDL-C比值和一般资料的差异,采用多因素logistic回归分析TG/HDL-C比值对CHD的致病风险,受试者工作特征(ROC)曲线评价其诊断价值。结果CHD组的TG/HDL-C比值、TG水平、高血压病史及CHD家族史占比均明显高于非CHD组,而HDL-C水平明显低于非CHD组,差异均有统计学意义(均P<0.05)。多因素logistic回归分析显示,TG(OR=1.021,P<0.001)、TG/HDL-C比值(OR=4.231,P=0.006)、高血压病史(OR=5.724,P<0.001)、CHD家族史(OR=3.614,P<0.001)均是CHD发病的独立危险因素,而HDL-C(OR=0.196,P=0.010)为其保护因素。ROC曲线分析显示TG、HDL-C和TG/HDL-C比值中以TG/HDL-C比值的曲线下面积(AUC)最大(AUC=0.985,P<0.05)。结论CHD患者的TG/HDL-C比值明显高于非CHD患者,其对CHD的诊断价值较高,且是CHD发病的的独立危险因素。Objective To investigate the relationship between triglyceride/high density lipoprotein cholesterol(TG/HDL-C)ratio and the risk of coronary heart disease(CHD)and its diagnostic value.Methods One hundred patients with CHD(CHD group)and 100 patients without CHD(non-CHD group)admitted to the People’s Hospital of Liaoning Province from June 2017 to June 2019 were selected as the research objects.The differences of TG/HDL-C ratio and general data between the two groups were compared.The risk of CHD induced by TG/HDL-C ratio was analyzed by multivariate logistic regression.Receiver operating characteristic(ROC)curve was used to evaluate its diagnostic value.Results The levels of TG/HDL-C ratio and TG and the percentages of history of hypertension and family history of CHD in CHD group were significantly higher than those in non-CHD group,while the level of HDL-C was significantly lower than that in non-CHD group,the differences were statistically significant(all P<0.05).Multivariate logistic regression analysis showed that TG(OR=1.021,P<0.001),TG/HDL-C ratio(OR=4.231,P=0.006),history of hypertension(OR=5.724,P<0.001)and family history of CHD(OR=3.614,P<0.001)were all independent risk factors for CHD,while HDL-C(OR=0.196,P=0.010)were protective factors.ROC curve analysis showed that among TG,HDL-C and TG/HDL-C ratios,the area under curve(AUC)of TG/HDL-C ratio was the largest(AUC=0.859,P<0.05).Conclusion The TG/HDL-C ratio of CHD patients is significantly higher than that of non-CHD patients,which has higher diagnostic value for CHD and is an independent risk factor for the occurrence of CHD.

关 键 词：冠心病 三酰甘油/高密度脂蛋白胆固醇比值 危险因素 诊断价值 

分 类 号：R541.4[医药卫生—心血管疾病]