抗感颗粒(儿童装)对普通型手足口病患儿免疫功能及炎性因子的影响  

The Influence of Kanggan Granules(for children)on Immunologic Function and Inflammatory Factor in Children Suffering Common Hand-foot-and-mouth Disease

作　　者：李宏云[1] 胡榕[1] 汪明辉[1] 张晓清 沈咏梅 黄媛莉 王亚云 王存林 LI Hongyun;HU Rong;WANG Minghui;ZHANG Xiaoqing;SHEN Yongmei;HUANG Yuanli;WANG Yayun;WANG Cunlin(Changde City the First People's Hospital,Changde 415003,China;Chengdu Hi-tech Good doctor First Affiliated Hospital)

机构地区：[1]常德市第一人民医院,湖南常德415003 [2]成都高新好医生第一医院

出　　处：《西部中医药》2021年第4期1-4,共4页Western Journal of Traditional Chinese Medicine

基　　金：湖南省卫生计生委科研计划课题(B20180434)。

摘　　要：目的:探讨抗感颗粒(儿童装)对轻症型手足口病儿童免疫功能及炎性因子的影响。方法:将60例普通型手足口病患儿随机分为观察组与对照组各30例。两组均给予单磷酸阿糖腺苷治疗,观察组在此基础上给予抗感颗粒(儿童装)口服治疗。观察治疗前及治疗5天后两组免疫指标及炎性因子水平。结果:治疗后,观察组免疫球蛋白A(immunoglobulin A,IgA)较治疗前显著升高,免疫球蛋白M(immunoglobulin M,IgM)、免疫球蛋白G(immunoglobulin G,IgG)较治疗前显著下降,差异有统计学意义(P<0.05);治疗后,观察组IgA高于对照组,IgM、IgG显著低于对照组,差异有统计学意义(P<0.05)。治疗后,两组CD3^(+)、CD4^(+)、CD8^(+)显著升高,CD19^(+)淋巴细胞水平均较治疗前显著下降,CD4^(+)/CD8^(+)较治疗前升高,差异均有统计学意义(P<0.05);治疗后,观察组CD3^(+)、CD4^(+)、CD8^(+)显著高于对照组,CD19^(+)淋巴细胞水平均显著低于对照组,CD4^(+)/CD8^(+)高于对照组,差异有统计学意义(P<0.05)。治疗后,两组白细胞介素2(interleukin-2,IL-2)、白细胞介素4(interleukin-4,IL-4)、白细胞介素6(interleukin-6,IL-6)、白细胞介素10(interleukin-10,IL-10)、肿瘤坏死因子α(tumor necrosis factorα,TNF-α)、干扰素γ(interferon-γ,IFN-γ)均较治疗前显著下降,差异有统计学意义(P<0.05);治疗后,观察组IL-2、IL-4、IL-6、IL-10、TNF-α、IFN-γ显著低于对照组,差异有统计学意义(P<0.05)。结论:抗感颗粒(儿童装)能够提高普通型手足口病患儿的免疫功能,降低炎性因子水平,从而改善患儿临床症状。Objective:To discuss the effects of Kanggan granules(for children)on immunologic function and inflammatory factors in children with mild hand-foot-and-mouth disease(HFMD).Methods:Sixty children were randomly allocated to the observation group and the control group,30 cases in each group.Both groups were given adenosine monophosphate,and the observation group took Kanggan granules(for children)orally based on Western medicine therapy.To detect the immune indexes and inflammatory factors of both groups before treating and five days after treating respectively.Results:After treating,IgA of the observation group soared compared with before treating,IgM and IgG dropped than before treating,and the difference had statistical meaning(P<0.05);after treating,IgA of the observation group was higher than that of the control group,IgM and IgG were lower than these of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of CD3^(+),CD4^(+)and CD8^(+)increased notably in both groups,the levels of CD19^(+)decreased remarkably compared with before treating,CD4^(+)/CD8^(+)lifted compared with before treating,and the difference had statistical meaning(P<0.05);After treatment,the levels of CD3^(+),CD4^(+)and CD8^(+)of the observation group were notably higher than these of the control group,the levels of CD19^(+)lower than these of the control group,CD4^(+)/CD8^(+)higher than that of the control group,and there were the significant differences(P<0.05).After treatment,the levels of IL-2,IL-4,IL-6,IL-10,TNF-αand IFN-γin both groups lowered notably compared with before treatment,and the difference had statistical meaning(P<0.05);after treating,the observation group was lower than the control group in the levels of IL-2,IL-4,IL-6,IL-10,TNF-αand IFN-γnotably,the difference was statistically significant(P<0.05).Conclusion:Kanggan granules(for children)could improve immunologic function in children with mild HFMD,lower the levels of inflammatory factors,thus improving clinical symptoms.

关 键 词：手足口病 普通型 抗感颗粒 免疫功能 炎性因子 

分 类 号：R246.4[医药卫生—针灸推拿学]