炙甘草汤联合卡维地洛对老年2型糖尿病合并心律失常患者血清炎症因子水平的影响  

Influence of Zhigancao Tang Combined with Carvedilol on the Levels of Serum Inflammatory Factor in the Elderly with Type Two Diabetes Mellitus and Arrhythmia

作　　者：陈伟[1] CHEN Wei(Tangshan City Hospital of Traditional Chinese Medicine,Tangshan 063000,China)

机构地区：[1]唐山市中医院,河北唐山063000

出　　处：《西部中医药》2021年第4期109-113,共5页Western Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2018319)。

摘　　要：目的:探讨炙甘草汤联合卡维地洛对老年2型糖尿病(type 2 diabetes mellitus,T2DM)合并心律失常患者血清炎症因子水平的影响。方法:选取T2DM合并心律失常患者86例,随机分为对照组和观察组,每组43例。对照组予卡维地洛片,观察组加服炙甘草汤,两组共治疗12周。比较两组收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)、心率(heart rate,HR),检测心率变异性(heart rate variability,HRV)指标[全部窦性心搏RR间期标准差(standard diviation of NN intervals,SDNN)、RR间期平均值标准差(standard diviation average of NN intervals,SDANN)、相邻RR间期差值均方根(root mean square of the successive normal sinus R-R interval difference,RMSSD)、相邻NN之差超过50 ms百分比(Adjacent NN interval difference 50ms percentage,PNN50)]及QT离散度(QT dispersion,QTd),比较血清炎症因子[超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、白细胞介素6(Interleukin 6,IL-6)、肿瘤坏死因子α(tumor necrosis factorα,TNF-α)]水平,评价临床疗效。结果:SBP、DBP、HR、SDNN、SDANN、RMSSD、PNN50、QTd值,血清hs-CRP、IL-6、TNF-α水平,与同组治疗前比较差异均有统计学意义(P>0.05);治疗后QTd两组比较差异无统计学意义(P>0.05),其余各项指标观察组改善程度均优于对照组(P<0.01);观察组临床有效率为90.70%(39/43),高于对照组的74.42%(32/43)(P<0.05)。结论:炙甘草汤联合卡维地洛治疗T2DM合并心律失常疗效显著,可能与调控机体炎症因子表达有关。Objective:To explore the effects of Zhigancao Tang and carvedilol on the levels of serum inflammatory factor in the elderly with type two diabetes mellitus(T2DM)and arrhythmia.Methods:All 86 patients were chosen,randomized into the control group and the observation group,43 cases each group.The control group was given carvedilol tablets,and the observation group took modified Zhigancao Tang,both groups were treated for 12 weeks.To compare SBP,DBP and HR between both groups,to detect the indexes of HRV(SDNN,SDANN,RMSSD,PNN50 and QTd),to measure the levels of serum inflammatory factors(hs-CRP,IL-6 and TNF-α),and assess clinical effects.Results:The difference had statistical meaning in the comparisons of SBP,DBP,HR,SDNN,SDANN,RMSSD,PNN50,QTd values,the levels of hs-CRP,IL-6 and TNF-αwithin the group before and after treating(P>0.05);the difference had no statistical meaning in QTd values between both groups after treating(P>0.05),the observation group was superior to the control group in the improvements of other indexes(P<0.01);clinical effective rate of the observation group was 90.70%(39/43),higher than 74.42%(32/43)of the control group(P<0.05).Conclusion:Zhigancao Tang and carvedilol are effective in treating the patients with T2DM and arrhythmia,and it might be related to regulating the expressions of inflammatory factors.

关 键 词：2型糖尿病 心律失常 炙甘草汤 卡维地洛 炎症因子 

分 类 号：R587.1[医药卫生—内分泌]