Ⅰ型先天性厚甲症一例  

Pachyonychia congenita type 1:a case report

作　　者：刘忠艳 王启华 周桂芝[2] LIU Zhongyan;WANG Qihua;ZHOU Guizhi(Department of Dermatology,Linyi Dermatology Hospital,Linyi Institute of Dermatology,Linyi 276000,China;Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and Venereology,Shandong First Medical University,Jinan 250022,China)

机构地区：[1]临沂市皮肤病医院皮肤科,临沂市皮肤病防治所,临沂276000 [2]山东第一医科大学附属皮肤病医院(山东省皮肤病医院,山东省皮肤病性病防治研究所),济南250022

出　　处：《中国麻风皮肤病杂志》2021年第5期315-316,共2页China Journal of Leprosy and Skin Diseases

摘　　要：患儿,女,11岁。厚甲、掌跖角化11年,其父亲有类似病史。皮肤科检查:指(趾)甲甲板增厚,口角结黄痂,口唇线状白斑,舌苔厚白,躯干及四肢皮肤多处角化过度。皮肤组织病理示:表皮高度角化过度、角化不全、棘层增厚,真皮乳头血管扩张、充血,周围少许组织细胞浸润。诊断:I型先天性厚甲症。A 11-year-old female is hereby reported, who presented with subungual hyperkeratosis, yellow scab on the corner of the mouth, oral leukokeratosis and numerous hyperkeratosis lesions all over the body. Histological examination showed hyperkeratosis and parakeratosis of epidermis, acanthosis, dilation and hyperemia of dermal papilla vessels, and histiocytic infiltration surrounding vessels. The features were consistent with a diagnosis of pachyonychia congenita type 1. Her father has a similar history.

关 键 词：先天性厚甲症 

分 类 号：R758.72[医药卫生—皮肤病学与性病学]