非桥粒芯糖蛋白抗体在寻常型天疱疮中的作用机制  

Update of non-desmoglein IgG autoantibodies in the pathogenesis of pemphigus vulgaris

作　　者：谢志敏 沈旭成 戴向农[1,2] 李青青 叶兴东 XIE Zhimin;SHEN Xuchen;DAI Xiangnong;LI Qingqing;YE Xingdong(Department of Dermatology,Guangzhou Institute of Dermatology,Guangzhou 510095,China;Institute of Dermatology,Guangzhou Medical University,Guangzhou 510095,China)

机构地区：[1]广州市皮肤病防治所皮肤科,广州510095 [2]广州医科大学皮肤病研究所皮肤科,广州510095

出　　处：《中国麻风皮肤病杂志》2021年第5期324-327,共4页China Journal of Leprosy and Skin Diseases

基　　金：广州市科技计划项目(编号:201904010352)。

摘　　要：既往发现寻常型天疱疮(pemphigus vulgaris,PV)发病机制与桥粒芯糖蛋白1(desmoglein,Dsg1)和Dsg3抗体有关,目前在PV患者中发现大量非Dsg自身免疫性抗体,包括桥粒胶蛋白1(desmocollin,Dsc1)和Dsc3、斑菲素蛋白1(plakophilin,PKP1)和PKP3、斑珠蛋白(plakoglobin,PG)、桥粒斑蛋白(desmoplakin,DP)、乙酰胆碱受体等。本文对非Dsg蛋白在PV发病机制中的作用进行了综述。The the pathogenesis of pemphigus vulgaris(PV)was associated with autoantibodies against desmosomal cadherin,desmoglein1(Dsg1)and Dsg3 in previous studies,and now many non-Dsg autoantibodies were reported including desmocollin(Dsc)1 and Dsc3,plakophilin(PKP)1 and PKP3,plakoglobin(PG),desmoplakin(DP),acetylcholine receptor(AChR),secretory pathway Ca 2+/Mn 2+-ATPase isoform 1(SPCA1),thyroid peroxidase(TPO)and mitochondrial protein.The non-Dsg autoantibodies associated with pathogenesis of PV were reviewed in this paper.

关 键 词：寻常型天疱疮 桥粒胶蛋白 斑菲素蛋白 乙酰胆碱受体 甲状腺过氧化物酶 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]