血清一般代谢指标与中老年原发性高血压的相关性  

Correlation between serum general metabolic indexes and essential hypertension in middle-aged and elderly patients

作　　者：朱小雨 冉利梅 谭玉洁 徐殿琴 黄海 ZHU Xiaoyu;RAN Limei;TAN Yujie;XU Dianqin;HUANG Hai(School of Medical Laboratory,Guizhou Medical University,Guiyang 550004,Guizhou,China;Health Management Center,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China;Clinical Laboratory Center,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China;Department of Hypertension,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China)

机构地区：[1]贵州医科大学医学检验学院,贵州贵阳550004 [2]贵州医科大学附属医院健康管理中心,贵州贵阳550004 [3]贵州医科大学附属医院临床检验中心,贵州贵阳550004 [4]贵州医科大学附属医院高血压科,贵州贵阳550004

出　　处：《贵州医科大学学报》2021年第4期447-450,共4页Journal of Guizhou Medical University

基　　金：贵州省科技计划项目[黔科合平台人才(2019)5610]。

摘　　要：目的探讨血清25-羟维生素D[25(OH)D]、尿素(UREA)、肌酐(CREA)、尿酸(UA)、葡萄糖(GLU)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)水平与中老年原发性高血压发生的关系。方法选择体检中心人群中符合中老年原发性高血压诊断的患者67人作为高血压组,同期年龄性别匹配的健康体检者46人作为对照组;采用台式血压计测量2组研究对象安静状态下的舒张压(DBP)和收缩压(SBP),同时抽取空腹肘静脉血3~5 mL,采用罗氏全自动生化分析仪检测2组研究对象血清25(OH)D、UREA、CREA、UA、GLU、TC、HDL-C及LDL-C水平;采用Logistic回归分析评估中老年原发性高血压的危险因素。结果2组研究对象血清CREA、UA、GLU、TC、LDL-C、HDL-C及SBP、DBP均值等比较,差异均有统计学意义(P<0.05);Logistic回归模型分析结果显示,UA和LDL-C是中老年原发性高血压的危险因素(OR分别为1.010和3.322,95%CI分别为1.002~1.017和1.532~7.247)。结论血清UA、GLU、LDL-C及TC等一般代谢指标与中老年原发性高血压的发生相关,其中UA和LDL-C是影响其发生的危险因素。Objective To explore the relationship between the level of 25-hydroxyvitamin D[25(OH)D],UREA,creatinine(CREA),uric acid(UA),glucose(GLU),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),and low density lipoprotein cholesterol(LDL-C),and the occurrence of essential hypertension in middle-aged and elderly patients.Methods Sixtyseven middle-aged and elderly patients with essential hypertension were selected as the middle-aged and elderly essential hypertension group,and 46 age-and sex-matched healthy people in the same period served as control group.The diastolic blood pressure(DBP)and systolic blood pressure(SBP)of the two groups were measured by desk model sphygmomanometer,and 3 to 5 mL fasting elbow venous blood was taken at the same time.Roche automatic biochemical analyzer was used to detect 25(OH)D,UREA,CREA,UA,GLU,TC,HDL-C,and LDL-C in serum of two groups of subjects.Logistic regression analysis was used to evaluate the risk factors of essential hypertension in middle-aged and elderly patients.Results Serum CREA,UA,GLU,TC,LDL-C,HDL-C,SBP,and DBP mean were compared between the two groups,and the differences were statistically significant(P<0.05).Logistic regression analysis showed that UA and LDL-C were risk factors for essential hypertension in middle-aged and elderly patients(OR value was 1.010 and 3.322,95%CI was 1.002-1.017 and 1.532-7.247,respectively).Conclusion General metabolic indexes such as serum UA,GLU,LDL-C,and TC are related to the occurrence of essential hypertension in the middle-aged and elderly,and UA and LDL-C are the risk factors affecting the occurrence of essential hypertension.

关 键 词：尿酸 血清 危险因素 中老年原发性高血压 脂蛋白 收缩压 舒张压 

分 类 号：R544.1[医药卫生—心血管疾病]