微脉冲激光或传统格栅光凝联合康柏西普治疗糖尿病黄斑水肿的临床分析  

Clinical Analysis of Micropulse Laser or Traditional Grid Photocoagulation Combined with Conbercept in the Treatment of Diabetic Macular Edema

作　　者：陈彦茹 李明翰 CHEN Yanru;LI Minghan(Xiamen Eye Center Affiliated to Xiamen University,Xiamen,Fujian Province,361000 China)

机构地区：[1]厦门大学附属厦门眼科中心,福建厦门361000

出　　处：《糖尿病新世界》2021年第5期29-31,共3页Diabetes New World Magazine

基　　金：厦门市科技惠民项目(3502Z20174002)。

摘　　要：目的观察微脉冲激光或传统格栅光凝联合康柏西普治疗糖尿病黄斑水肿(DME)的有效性、安全性。方法纳入2017年1月—2019年6月DME患者98眼,577 nm阈值下微脉冲联合治疗(A组)32眼、传统格栅光凝联合治疗(B组)30只眼、单纯康柏西普治疗(C组)36眼。观察最佳矫正视力(BCVA)、黄斑中心凹厚度(CFT)、黄斑容积(MV)及视网膜的微结构变化及注射针数。结果所有患者治疗后3、6、9、12个月的BCVA、CFT、MV均较前改善,差异有统计学意义(F=39.558、62.901、10.078,P<0.001)。组间比较差异无统计学意义(F=0.417、0.085、0.061,P=0.513、0.675、0.823)。A、B组年平均药物注射次数分别为(6.3±0.9)、(6.5±1.1)次低于C组(8.6±2.2)次,差异有统计学意义(F=7.980,P<0.05)。B组可见激光损伤而A组未见。结论激光联合治疗与单纯药物治疗均对DME有效,联合治疗可减少药物注射次数;微脉冲激光较传统格栅光凝更安全。Objective To observe the effectiveness and safety of micropulse laser or traditional grid photocoagulation combined with Conbercept in the treatment of diabetic macular edema(DME).Methods From January 2017 to June 2019,98 eyes of DME patients were enrolled,32 eyes were treated with micropulse at 577nm threshold(group A),30 eyes were treated with traditional grid photocoagulation(group B),and only CompaXil General treatment(group C)36 eyes.Observe the best corrected visual acuity(BCVA),macular foveal thickness(CFT),macular volume(MV),changes in the microstructure of the retina and the number of injection needles.Results The BCVA,CFT,and MV of all patients at 3,6,9,12 months after treatment were improved compared to before,and the difference was statistically significant(F=39.558,62.901,10.078,P<0.001).Compared between groups,the difference was not statistically significant(F=0.417,0.085,0.061,P=0.513,0.675,0.823).The average annual drug injections times in groups A and B were(6.3±0.9)times and(6.5±1.1)times lower than those in group C(8.6±2.2)times,respectively.The difference was statistically significant(F=7.980,P<0.05).Laser damage was seen in group B but not in group A.Conclusion Both laser combination therapy and drug therapy alone are effective for DME.Combined therapy can reduce the number of drug injections;micropulse laser is safer than traditional grid photocoagulation.

关 键 词：糖尿病视网膜病变 黄斑水肿 血管生成抑制剂 激光凝固术 

分 类 号：R59[医药卫生—内科学]