解毒化浊法对湿热下注型慢性肛窦炎患者炎症因子、免疫功能及氧化应激的影响  

Effect of Toxin-Removing and Turbidity-Resolving Method on Inflammatory Factors,Immune Function,and Oxidative Stress in Patients with Chronic Anal Sinusitis of Dampness-Heat Pouring Down Syndrome

作　　者：卢瑞云[1] 刘璞 祁亚卓[1] 张伟玲[1] 张桂芳 魏明[1] LU Ruiyun;LIU Pu;QI Yazhuo;ZHANG Weiling;ZHANG Guifang;WEI Ming(Gastrointestinal Surgery Department,The First Hospital of Hebei Medical University,Shijiazhuang 050039,China)

机构地区：[1]河北医科大学第一医院胃肠外科,河北石家庄050039

出　　处：《山东中医杂志》2021年第5期471-475,共5页Shandong Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局中医药科研计划项目(编号:2017179)。

摘　　要：目的:探讨解毒化浊法对湿热下注型慢性肛窦炎患者炎症因子、免疫功能及氧化应激的影响。方法:将120例湿热下注型慢性肛窦炎患者按随机数字表法分为对照组和治疗组各60例,对照组给予地奥司明片口服配合高锰酸钾溶液坐浴,治疗组采用解毒化浊内服方和坐浴方治疗,两组患者均连续治疗2周。检测两组患者治疗前后血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、CD3、CD4、CD8、CD4/CD8、超氧化物歧化酶(SOD)、丙二醛(MDA)水平,比较两组患者治疗后的中医证候疗效、复发率和不良反应情况。结果:治疗后,治疗组中医证候总有效率90.00%,对照组中医证候总有效率66.67%,两组疗效比较,差异有统计学意义(P<0.05)。两组患者CRP、IL-6、IL-8、TNF-α水平较治疗前均下降(P<0.05),且治疗组水平低于对照组(P<0.01)。两组患者CD3、CD4和CD4/CD8水平较治疗前均上升(P<0.05),CD8水平较治疗前均下降(P<0.05),且治疗组上述变化幅度大于对照组(P<0.01)。两组患者SOD水平较治疗前均下降(P<0.001),MDA水平较治疗前均上升(P<0.001),且治疗组上述变化幅度大于对照组(P<0.001)。治疗组患者2个月、4个月、6个月的复发率均低于对照组(P<0.05)。治疗组、对照组不良反应发生率分别为5.00%、6.67%,差异无统计学意义(P>0.05)。结论:运用解毒化浊法治疗湿热下注型慢性肛窦炎能减轻炎症反应,调节机体免疫功能,改善氧化应激状态,且疗效较好,复发率低,不良反应少,安全性高。Objective:To investigate the effect of toxin-removing and turbidity-resolving method on inflammatory factors,immune function,and oxidative stress in patients with chronic anal sinusitis of dampness-heat pouring down syndrome.Methods:A total of 120 patients with chronic anal sinusitis of dampness-heat pouring down syndrome were divided into control group and treatment group according to the random number table method,with 60 cases in each group.Patients in the control group were given Diosmin tablets orally,combined with potassium permanganate sitz bath,and those in the treatment group were given two toxin-removing and turbidity-resolving prescirtions,one for internal use,the other for sitz bath.Patients in both groups were treated for 2 weeks.Serum levels of C-reactive protein(CRP),interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),CD3,CD4,CD8,CD4/CD8,superoxide dismutase(SOD),and malondialdehyde(MDA)of the patients in the two groups were measured before and after treatment,and the efficacy on traditional Chinese medicine symptoms,recurrence rate and adverse reactions of the two groups were compared after treatment.Results:After treatment,the total effective rate of traditional Chinese medicine symptoms in the treatment group was 90.00%and that in the control group was 66.67%.The difference of curative efficacy between the two groups was statistically significant(P<0.05).The levels of CRP,IL-6,IL-8,and TNF-α of the two groups after treatment decreased significantly as compared with those before treatment(P<0.05),and the decrease in the treatment group was more significant(P<0.01).After treatment,both groups showed higher levels of CD3,CD4 and CD4/CD8 but lower level of CD8 than before treatment(P<0.05),and the changes in the treatment group were greater than those in the control group(P<0.01).Both groups showed lower level of SOD but higher level of MDA than before treatment(P<0.001),and the changes in the treatment group were greater than those in the control group(P<0.001).The 2-month,4-m

关 键 词：解毒化浊法 湿热下注 慢性肛窦炎 免疫功能 氧化应激 炎症因子 

分 类 号：R266[医药卫生—中医外科学]