不同年龄和基础疾病的COVID-19患者血液学指标和病情分析  

Analysis of hematological indexes and conditions of COVID-19 patients with different ages and underlying diseases

作　　者：余桥 吉攀 朱洁云 宾雁飞 谢周华[3] 张剑锋[1] 沈印[2] YU Qiao;JI Pan;ZHU Jie-yun(Department of Emergency Medicine, the Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, China)

机构地区：[1]广西医科大学第二附属医院急诊科,南宁530007 [2]广西壮族自治区人民医院国际医疗部,南宁530021 [3]南宁市第四人民医院结核科,广西530000

出　　处：《中国临床新医学》2021年第4期380-384,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：国家自然科学基金项目(编号:81960343);广西重点研发计划防控新型冠状病毒感染肺炎疫情应急科技攻关专项(编号:桂科AB20058002)。

摘　　要：目的分析比较不同年龄和基础疾病2019新型冠状病毒肺炎(COVID-19)患者的血液学指标和病情严重程度。方法选择2020-01-22~2020-02-29广西南宁市第四人民医院及武汉市黄陂区中医医院收治的150例COVID-19患者为研究对象,按年龄分为青年组(18~39岁,51例)、中年组(40~59岁,50例)、老年组(≥60岁,49例);按合并基础疾病情况分为无基础疾病组(126例)和合并基础疾病组(24例)。比较各组的一般临床资料及血液学指标。结果老年组合并基础疾病的人数比例最高,中年组次之,青年组最低,差异有统计学意义(P<0.05)。老年组和中年组的重症人数比例显著高于青年组(P<0.05)。三组淋巴细胞计数、红细胞计数和血红蛋白水平比较差异有统计学意义(P<0.05),以老年组水平较低。三组D-二聚体、乳酸脱氢酶、总胆红素和血尿素氮水平比较差异有统计学意义(P<0.05),以老年组水平较高。与无基础疾病组比较,合并基础疾病组的年龄更大,D-二聚体、乳酸脱氢酶水平更高,差异有统计学意义(P<0.05)。结论中老年COVID-19患者合并的基础疾病更多,重症率更高。高龄、合并基础疾病可能是COVID-19患者病情加重的危险因素。Objective To analyze and compare the hematological indexes and the severity of coronavirus disease 2019(COVID-19)in patients with different ages and underlying diseases.Methods One hundred and fifty COVID-19 patients admitted to Guangxi Nanning Fourth People′s Hospital and Huangpi District Chinese Medicine Hospital of Wuhan from January 22,2020 to February 29,2020 were selected as the research subjects.According to their ages,the patients were divided into young group(18-39 years old,51 cases),middle-aged group(40-59 years old,50 cases)and elderly group(≥60 years old,49 cases);and the patients were divided into non-concomitant underlying disease group(126 cases)and concomitant underlying disease group(24 cases)according to their concomitant underlying diseases.The general clinical data and hematological indexes were compared among the groups.Results The elderly group had the largest proportion of the patients with concomitant underlying diseases,followed by the middle-aged group and the young group,and the difference was statistically significant(P<0.05).The proportion of severe cases in the elderly group and the middle-aged group was significantly higher than that in the young group(P<0.05).There were significant differences in the lymphocyte count,red blood cell count and hemoglobin level among the three groups(P<0.05),and the levels of the elderly group were the lowest(P<0.05).There were significant differences in the levels of D-dimer,lactate dehydrogenase(LDH),total bilirubin(TBil)and blood urea nitrogen(BUN)among the three groups,and the levels of the elderly group were the highest(P<0.05).Compared with those in the non-concomitant underlying disease group,the patients in the concomitant underlying disease group were older,and had higher D-dimer and LDH levels,and the differences were statistically significant(P<0.05).Conclusion Middle-aged and elderly patients with COVID-19 have more concomitant underlying diseases and a higher rate of severe cases.Old age and concomitant underlying diseases may be the

关 键 词：2019新型冠状病毒肺炎 血液学指标 年龄 基础疾病 

分 类 号：R512.99[医药卫生—内科学]