雾化吸入干扰素α2b注射液治疗小儿呼吸道合胞病毒肺炎的临床效果  

Clinical effect of atomized inhalation of interferonα2b injection in the treatment of children with respiratory syncytial virus pneumonia

作　　者：崔鸿鹤 CUI Honghe(Huaibin County Third People's Hospital,Xinyang 464400,China)

机构地区：[1]河南省淮滨县第三人民医院,河南信阳464400

出　　处：《临床医学研究与实践》2021年第13期90-92,共3页Clinical Research and Practice

摘　　要：目的分析雾化吸入干扰素α2b注射液治疗小儿呼吸道合胞病毒肺炎的临床效果。方法回顾性选取2018年6月至2020年6月本院收治的100例呼吸道合胞病毒肺炎患儿,依据治疗方法将其分为常规治疗组(n=50,常规药物)和雾化吸入组(n=50,在常规治疗基础上雾化吸入干扰素α2b注射液)。比较两组的血清炎症因子水平、临床疗效、症状体征消失时间、不良反应发生情况。结果治疗后,两组IL-10水平均高于治疗前,IL-18、TNF-α水平均低于治疗前,且雾化吸入组优于常规治疗组(P<0.05)。雾化吸入组的治疗总有效率高于常规治疗组(P<0.05)。雾化吸入组的发热、咳嗽、喘憋、肺部啰音消失时间均短于常规治疗组(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论雾化吸入干扰素α2b注射液治疗小儿呼吸道合胞病毒肺炎的效果较好,且不会增加患儿的不良反应。Objective To analyze the clinical effect of atomized inhalation of interferonα2b injection in the treatment of children with respiratory syncytial virus pneumonia.Methods A total of 100 children with respiratory syncytial virus pneumonia admitted in our hospital from June 2018 to June 2020 were selected retrospectively.According to the treatment methods,the children were divided into conventional treatment group(n=50,conventional drugs)and atomized inhalation group(n=50,atomized inhalation of interferonα2b injection on the basis of conventional treatment).The levels of serum inflammatory factors,clinical efficacy,disappearance time of symptoms and signs,and occurrence of adverse reactions were compared between the two groups.Results After treatment,the levels of IL-10 in the two groups were higher than that before treatment,and the levels of IL-18 and TNF-αwere lower than those before treatment,and those in the atomized inhalation group were better than the conventional treatment group(P<0.05).The total effective rate of treatment of the atomized inhalation group was higher than that of the conventional treatment group(P<0.05).The disappearance time of fever,cough,wheezing and pulmonary rales in the atomized inhalation group were shorter than those in the conventional treatment group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The atomized inhalation of interferonα2b injection in the treatment of children with respiratory syncytial virus pneumonia has a good effect,and it will not increase the adverse reactions of children.

关 键 词：小儿呼吸道合胞病毒肺炎 雾化吸入 干扰素α2b注射液 不良反应 

分 类 号：R725.6[医药卫生—儿科]