抗菌剂用于牙科复合树脂的研究进展  

Research progress of antibacterial agents used in dental resin composites

作　　者：毛驭川 张璐斯 陈红艳 王瑞莉 朱美芳[1,2] MAO Yuchuan;ZHANG Lusi;CHEN Hongyan;WANG Ruili;ZHU Meifang(College of Material Science and Engineering,Donghua University,Shanghai 201620,China;State Key Laboratory for Modifcation of Chemical Fibers and Polymer Materials(Donghua University),Shanghai 201620,China)

机构地区：[1]东华大学材料科学与工程学院,上海221022 [2].纤维材料改性国家重点实验室(东华大学),上海221020

出　　处：《材料科学与工艺》2021年第2期1-19,共19页Materials Science and Technology

基　　金：国家重点研发计划项目(2016YFA0201702);中央高校基本科研业务费专项资金项目(2232018D3-11);国家自然科学基金项目(51903042);上海市浦江人才计划(18PJ1400300)。

摘　　要：龋病是常见的口腔疾病,填充修复是治疗的重要手段。复合树脂凭借色泽美观和理化性能优异等特点,广泛应用于牙科修复材料中。继发龋是临床应用中导致修复失败的主要原因之一。为了抑制继发龋、延长树脂使用寿命,研发具有长期抗菌功能的牙科复合树脂具有重要意义。目前,主要通过向复合树脂体系中添加抗菌型无机粒子或抗菌型有机单体赋予材料抗菌性能。基于抗菌剂的抗菌机理,本文概述了上述抗菌剂对复合树脂抗菌性能及理化性能影响的研究进展,指出了多数抗菌剂在满足复合树脂抗菌性能的同时,无法避免对树脂材料力学性能和美观性产生负面影响。最后,对抗菌型牙科复合树脂的发展趋势进行了展望,有助于推动该类材料的临床应用。Dental caries is a prevalent chronic oral disease,which is mainly repaired by filling repair materials.Dental resin composites have been widely used as dental restorative materials due to their excellent esthetics and physical-mechanical properties.However,secondary caries is still a major reason of repair failure in clinical applications.Therefore,it is necessary to develop functional dental composites with long-term antibacterial effect by introducing antibacterial inorganic particles and/or antibacterial monomers.Currently,it is mainly through adding antibacterial inorganic particles or antibacterial organic monomer in resin composite to give material antibacterial properties.Based on the antibacterial mechanisms,the research progress of the antibacterial properties and physicochemical properties of the above antibacterial agents on dental resin composites is summarized,which demonstrates that most antibacterial agents can hardly balance the mechanical properties,aesthetics,and antibacterial activity.Finally,the prospects for future development of antibacterial dental resin composites are also discussed,which can make contributions to promote the application of antibacterial agents in dental resin composite.

关 键 词：牙科复合树脂 继发龋 抗菌剂 抗菌机理 无机填料 有机单体 

分 类 号：TB332[一般工业技术—材料科学与工程]