低强度脉冲聚焦超声对早中期膝关节骨关节炎患者关节功能影响的研究  

Effect of focused low intensity pulsed ultrasound on joint function in patients with mild to moderate knee osteoarthritis

作　　者：王枰稀[1] 曾凡伟[1] 张东[1] 肖遥 WANG Ping-xi;ZENG Fan-wei;ZHANG Dong;XIAO Yao(Dazhou Central Hospital,Dazhou 635000,Sichuan,China)

机构地区：[1]达州市中心医院,四川达州635000

出　　处：《川北医学院学报》2021年第4期433-436,共4页Journal of North Sichuan Medical College

基　　金：四川省科技厅应用基础研究项目(2018JY0324);四川省达州市科技局应用基础项目(17YYJC0004)。

摘　　要：目的:探讨低强度脉冲聚焦超声(FLIPUS)对早中期膝关节骨关节炎(KOA)患者关节功能的影响。方法:选取100例早中期KOA患者,按治疗方式不同分为实验组和对照组,每组各50例。实验组接受FLIPUS联合盐酸曲马多缓释片进行治疗,对照组接受假FLIPUS联合盐酸曲马多缓释片进行治疗。两组患者均同时服用盐酸曲马多缓释片。分别在治疗前后对两组患者关节功能进行评分,并记录治疗期间出现的不良反应。结果:治疗前,两组患者JKOM、OKS评分比较,差异无统计学意义(P>0.05),在JKOM量表细分的5个子项目(VAS、膝关节疼痛和僵硬度、日常生活状态、日常活动状态、精神健康评分)评分比较,差异均无统计学意义(P>0.05)。治疗后,两组患者JKOM、OKS评分较治疗前均有下降(P<0.001),其中实验组下降更明显(P<0.001)。在JKOM量表细分的各个子项目的对比中,两组患者治疗后VAS、膝关节疼痛和僵硬度、日常生活状态、日常活动状态、精神健康评分较前均有下降(P<0.001),其中实验组下降更明显(P<0.001),实验组关节功能改善更显著。实验组治疗总有效率均高于对照组(P<0.001)。两组患者治疗期间无FLIPUS治疗相关不良反应发生。结论:FLIPUS能有效改善早中期KOA患者关节功能,无FLIPUS治疗相关不良反应发生,FLIPUS治疗早中期KOA安全有效。Objective:To investigate the effect of focused low intensity pulsed ultrasound(FLIPUS)on the functional status in patients with mild to moderate knee osteoarthritis(KOA).Methods:100 patients with KOA were divided into experimental group and control group auording to different treatment methods,50 cases in each group.The experimental group received FLIPUS plus tramadol hydrochloride sustained release tablets,while the control group received sham FLIPUS plus tramadol hydrochloride sustained release tablets,both groups were given tramadol hydrochloride sustained release tablets at the same time.The joint function of the two groups were scored before and after treatment,and the adverse reactions during the treatment were recorded.Results:Before treatment,there was no statistically significant difference in JKOM and OKS scores between the two groups(P>0.05),there was no statistically significant difference in the five sub items(VAS,knee pain and stiffness,state of daily living,state of daily activities,mental health score)of JKOM scale(P>0.05).After treatment,the jkom and OKS scores of the two groups were decreased compared with those before treatment(P<0.001),the experimental group decreased more significantly(P<0.001).In the comparison of each sub item of JKOM scale,VAS,knee pain and stiffness,state of daily living,state of daily activities and mental health scores of the two groups decreased after treatment(P<0.001),the experimental group decreased more significantly(P<0.001),the improvement of joint function in the experimental group was more significant.The total effective rate of the experimental group was higher than that of the control group(P<0.001).There were no FLIPUS-related adverse events during the interventions.Conclusion:FLIPUS can effectively improve the joint function of patients with mild to moderate KOA,and there is no adverse reaction related to flus treatment.FLIPUS is safe and effective in the treatment of mild to moderate KOA.

关 键 词：膝关节 骨关节炎 低强度脉冲聚焦超声 关节功能 

分 类 号：R454.4[医药卫生—治疗学]