二甲双胍联合紫杉醇和卡铂治疗对复发性卵巢上皮癌患者血清蛋白激酶B及胸苷激酶1水平的影响  

Effects of metformin combined with paclitaxel and carboplatin on serum protein kinase B and thymidine kinase 1 in patients with recurrent epithelial ovarian cancer

作　　者：高丽峰 苗晶 刘楠 张鸿清 王志华 GAO Li-feng;MIAO Jing;LIU Nan;ZHANG Hong-qing;WANG Zhi-hua(Department of Obstetrics and Gynecology,Zhangjiakou First Hospital,Zhangjiakou 075000,Hebei,China)

机构地区：[1]张家口市第一医院妇产科,河北张家口075000

出　　处：《川北医学院学报》2021年第4期468-471,共4页Journal of North Sichuan Medical College

基　　金：河北省张家口市重点研发计划项目(1921089D)。

摘　　要：目的:探讨二甲双胍联合紫杉醇和卡铂治疗对复发性卵巢上皮癌患者血清蛋白激酶B(PKB)及胸苷激酶1(TK1)水平的影响。方法:将120例复发性卵巢上皮癌患者分为对照组和观察组,每组各60例。对照组给予紫杉醇和卡铂进行治疗,观察组在对照组基础上增加二甲双胍治疗。比较两组患者总有效率、PKB阳性表达率、TK1水平、不良反应总发生率及生活质量改善情况。结果:治疗后,观察组临床总有效率高于对照组(P<0.05),PKB阳性表达率及血清中TK1水平低于对照组(P<0.05),且PKB阳性率与TK1水平呈正相关(r=0.451,P<0.05)。治疗期间观察组患者生活质量总改善率高于对照组(P<0.05),不良反应总发生率低于对照组,但差异无统计学意义(P>0.05)。结论:二甲双胍联合紫杉醇和卡铂可提高复发性卵巢上皮癌患者治疗总有效率,降低PKB阳性表达率及TK1水平,提高患者生活质量,且不会增加患者治疗期间不良反应的发生,值得推广使用。Objective:To investigate the effect of metformin combined with paclitaxel and carboplatin on serum protein kinase B and thymidine kinase 1 in patients with recurrent epithelial ovarian cancer.Methods:A total of 120 patients with recurrent epithelial ovarian cancer were randomly divided into control group(n=60)and observation group(n=60).The control group was treated with paclitaxel and carboplatin,and the observation group was treated with metformin on the basis of the control group.The total effective rate,the positive expression rate of PKB,the level of TK1,the total incidence of adverse reactions and the improvement of quality of life were counted and compared between the two groups.Results:After treatment,the total clinical effective rate of the observation group was significantly higher than that of the control group(P<0.05).The positive expression rate of PKB and the level of serum TK1 in the observation group were significantly lower than those in the control group(P<0.05).The positive rate of PKB was positively correlated with the level of TK1(r=0.451,P<0.05).During the treatment,the total improvement rate of quality of life in the observation group was significantly higher than that in the control group(P<0.05),the total incidence of adverse reactions in the observation group was lower than that in the control group,the difference was not statistically significant(P>0.05).Conclusion:Metformin combined with paclitaxel and carboplatin can significantly improve the total effective rate of patients with recurrent epithelial ovarian cancer,reduce the positive expression rate of PKB and the level of TK1,improve the quality of life of patients,and will not increase the incidence of adverse reactions during treatment,which is worthy of promotion.

关 键 词：复发性卵巢上皮癌 二甲双胍 紫杉醇 卡铂 蛋白激酶B 胸苷激酶1 

分 类 号：R246[医药卫生—针灸推拿学]