2017-2019年河北省CRPA临床分布特征及耐药性分析  

Analysis of clinical distribution characteristics and drug resistance of CRPA in Hebei Province during 2017-2019

作　　者：张伟[1,2] 詹明华[3] 时东彦[4] 侯欣[2] 王娜 李甲 李丽萍 李采青 赵建宏[4,7] 徐英春[2] ZHANG Wei;ZHAN Minghua;SHI Dongyan;HOU Xin;WANG Na;LI Jia;LI Liping;LI Caiqing;ZHAO Jianhong;XU Yingchun(Department of Microbiology,First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China;Department of Clinical Laboratory,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences/Beijing Key Laboratory of Invasive Fungal Disease Mechanism Research and Precision Diagnosis,Beijing 100730,China;Department of Clinical Laboratory,First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China;Department of clinical Laboratory,Second Hospital of Hebei Medical University,Shijiazhuang,Hebei 075000,China;Department of Hospital Infection Management,First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China;Department of Clinical Laboratory,Xuan′gang Hospital,Zhangjiakou,Hebei 075000,China;Faculty of Laboratory Medicine,Hebei Medical University/Hebei Provincial Center for Clinical Laboratory,Zhangjiakou,Hebei 075000,China)

机构地区：[1]河北北方学院附属第一医院微生物科,河北张家口075000 [2]中国医学科学院北京协和医院检验科/侵袭性真菌病机制研究与精准诊断北京市重点实验室,北京100730 [3]河北北方学院附属第一医院检验科,河北张家口075000 [4]河北医科大学第二医院检验科,石家庄050000 [5]河北北方学院附属第一医院院感管理科,河北张家口075000 [6]宣钢医院检验科,河北张家口075000 [7]河北医科大学医学检验系/河北省临床检验中心,石家庄050000

出　　处：《重庆医学》2021年第8期1338-1341,1346,共5页Chongqing medicine

基　　金：国家自然科学基金面上项目(81971979);河北省卫生健康委员会科研基金项目(20190904);河北省医学科学研究重点课题(20180843)。

摘　　要：目的研究2017-2019年河北省耐碳青霉烯类的铜绿假单胞菌(CRPA)临床分布特征及药物敏感性的变化情况。方法收集河北省2017-2019年CRPA 6536株,采用全自动药物敏感性分析仪器MIC法及K-B纸片扩散法对其进行药物敏感性试验,对实验数据进行统计分析。结果河北省2017-2019年CRPA感染患者男女比例约为2∶1,成年人和老年人分别占40%和55%,新生儿和未成年人分别占1%和4%。CRPA在总的铜绿假单胞菌占比从2017年的24.4%降至2019年的20.4%。2017-2019年,亚胺培南耐药率逐年上升、多粘菌素基本不变,其他抗菌药物的耐药率均逐年下降。结论2017-2019年河北省CRPA占比和耐药率均呈下降趋势。Objective To investigate the clinical distribution characteristics and drug susceptibility change of carbapenem resistant Pseudomonas aeruginosa(CRPA)in Hebei Province during 2017-2019.Methods A total of 6536 strains of CRPA in Hebei Province during 2017-2019 were collected.The automatic drug susceptibility analyzer MIC method and K-B disk diffusion method were used to conduct the drug sensitivity test.The experimental data were statistically analyzed.Results The ratio of male to female patients with CRPA infection in Hebei Province during 2017-2019 was 2∶1.The adults and elderly people accounted for 40%and 55%,respectively,while the newborns and minors accounted for 1%and 4%,respectively.The proportion of CRPA in the total Pseudomonas aeruginosa was dropped from 24.4%in 2017 to 20.4%in 2019.During 2017-2019,the resistance rate of imipenem was increased year by year,polymyxin remained basically unchanged,and the resistance rate of other antibacterial drugs was decreased year by year.Conclusion The proportion and drug resistance rate of CRPA in Hebei Province during 2017-2019 both showed a downward trend.

关 键 词：亚胺培南 美罗培南 铜绿假单胞菌 分布 耐药性 耐碳青霉烯类的铜绿假单胞菌 

分 类 号：R446.5[医药卫生—诊断学]