成纤维样滑膜细胞的生理功能及其在炎性关节病诊疗中的应用进展  

Physiological function of fibroblast like synoviocytes and its application advance in diagnosis and treatment of inflammatory arthropathy

作　　者：熊翱 熊仁平 彭艳(综述) 许建中(审校)[1] XIONG Ao;XIONG Renping;PENG Yan;XU Jianzhong(Department of Orthopedics,First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China;Army Characteristic Medical Center of PLA,Chongqing,400042,China)

机构地区：[1]郑州大学第一附属医院骨科,郑州450052 [2]中国人民解放军陆军特色医学中心野战外科研究部,重庆400042

出　　处：《重庆医学》2021年第8期1399-1403,共5页Chongqing medicine

基　　金：国家自然科学基金项目(81701915)。

摘　　要：运动障碍的主要原因是各类炎性关节病(IJD),关节滑膜的功能改变影响着患者的运动功能。滑膜组织中的滑膜成纤维样细胞(FLS),在生理状态下参与了骨关节的润滑和免疫调节及维持关节腔稳态;在病理状态下,参与了IJD的发生、发展,诱发关节炎症,破坏滑膜、关节软骨、关节。FLS在IJD病理过程中扮演着重要角色,为了深入研究FLS在IJD中的作用,搞清楚IJD的发病机制和寻求治疗靶点,FLS体外研究IJD是国内外热点。为此,本文将对FLS在生理和病理状态的功能及FLS在IJD诊疗中的应用进展进行综述,以期为IJD的病理机制研究和治疗靶点的探讨提供帮助。The main cause of dyskinesia is various kinds of inflammatory joint disease(IJD).The changes of joint synovium function affect the patients′motor function.In the physiological status,the fibroblast-like synovial cells(FLS)in the synovial tissue participate in the lubrication of bone and joint;in the pathological state which participate in the occurrence and development of IJD,induce arthritis and destroy the synovium,articular cartilage and joint.FLS plays an important role in the pathological process of(IJD).In order to further study the role of FLS in IJD,understand the pathogenesis of IJD and seek the treatment targets,the in vitro study on IJD for FLS is the hotspot at home and abroad.Therefore this paper reviews the function of FLS in physiological and pathological state,application progress of FLS in diagnosis and treatment of IJD in order to provide the help for the study of pathological mechanism and treatment target of IJD.

关 键 词：成纤维样滑膜细胞 炎性关节病 骨关节炎 综述 

分 类 号：Q95-33[生物学—动物学]