SAA、IL-6和INF-α在特发性间质性肺炎中的表达水平及联合检测在IIP中的诊断价值  

The expression levels of SAA,IL-6 and INF-αin idiopathic interstitial pneumonia and the diagnostic value of combined detection in IIP

作　　者：孙国磊 SUN Guo-lei(Emergency Department of Critical Care Medicine,Tianjin Jinnan Hospital,Tianjin 300350,China)

机构地区：[1]天津市津南医院重症医学急诊科,天津300350

出　　处：《吉林医学》2021年第5期1085-1088,共4页Jilin Medical Journal

摘　　要：目的:探讨SAA(血清淀粉样蛋白A)、IL-6(白细胞介素-6)和TNF-α(肿瘤坏死因子-α)在特发性间质性肺炎(IIP)中的表达水平及联合检测在IIP中的诊断价值。方法:选取2016年~2018年90例特发性间质性肺炎患者以及100例接受身体检查的健康人群为研究对象。将90例特发性间质性肺炎患者列为观察组,将100例健康人群列为对照组。用免疫比浊法检测测定血清淀粉样蛋白A,应用化学发光法测定白细胞介素-6、肿瘤坏死因子-α。结果:观察组90例患者的血清淀粉样蛋白A为(37.8±8.58)mg/L,明显高于对照组的(4.46±0.788)mg/L,差异有统计学意义(P<0.05);观察组白细胞介素-6值为(0.73±0.55)ng/ml,明显高于对照组的(0.28±0.37)ng/ml,差异有统计学意义(P<0.05);观察组的肿瘤坏死因子-α值为(5.46±0.09)ng/ml,明显高于对照组的(1.46±0.11)ng/ml,差异有统计学意义(P<0.05)。观察组的特发性间质性肺炎疾病中,普通型间质性肺炎患者血清淀粉样蛋白A、白细胞介素-6、肿瘤坏死因子-α表达,对比其他分型有明显的升高,差异有统计学意义(P<0.01);血清淀粉样蛋白A、白细胞介素-6、肿瘤坏死因子-α联测检测的阳性率,明显高于单指标检测的阳性率,差异有统计学意义(P<0.05)。结论:对血清淀粉样蛋白A、白细胞介素-6、肿瘤坏死因子-α表达水平的联合检测,对于诊断特发性间质性肺炎疾病,提示疾病严重程度,疾病分型具有较好的效果。三项测定联合诊断特发性间质性肺炎的效果,优于单指标检测诊断该疾病。Objective To explore the expression level and combination of SAA(serum amyloid A),IL-6(interleukin-6)and TNF-α(tumor necrosis factor-α)in idiopathic interstitial pneumonia The diagnostic value of testing in IIP.Method Ninety patients with idiopathic interstitial pneumonia admitted to our hospital from 2016 to 2018 and 100 healthy people who came to our hospital for physical examination were selected as the subjects of this study.Ninety patients with idiopathic interstitial pneumonia were listed as the observation group,and 100 healthy people as the control group.Serum amyloid A was detected by immunoturbidimetric method,and interleukin-6 and tumor necrosis factor-αwere determined by chemiluminescence method.Results The serum amyloid A of 90 patients in the observation group was(37.8±8.58)mg/L,which was significantly higher than that of the control group(4.46±0.788)mg/L(P<0.05);the observation group′s interleukin-The value of 6 was(0.73±0.55)ng/ml,which was significantly higher than the control group′s(0.28±0.37)ng/ml(P<0.05);the observation group′s tumor necrosis factor-αvalue was(5.46±0.09)ng/ml,significantly higher than the control group(1.46±0.11)ng/ml,(P<0.05).In the observation group of idiopathic interstitial pneumonia,the expression of serum amyloid A,interleukin-6,and tumor necrosis factor-αin patients with ordinary interstitial pneumonia was significantly higher than that of other types(P<0.01);The positive rate of combined detection of serum amyloid A,interleukin-6,and tumor necrosis factor-αwas significantly higher than the positive rate of single index detection(P<0.05).Conclusion The combined detection of the expression levels of serum amyloid A,interleukin-6,and tumor necrosis factor-αhas a good effect on the diagnosis of idiopathic interstitial pneumonia,indicating the severity of the disease and the classification of the disease.The combined diagnosis of idiopathic interstitial pneumonia by three tests is better than that of single index test in diagnosing the disease.

关 键 词：血清淀粉样蛋白A 白细胞介素-6 肿瘤坏死因子-α 特发性间质性肺炎 诊断价值 

分 类 号：R563.1[医药卫生—呼吸系统]