基于药效成分评价四制益母草炮制辅料的科学性  

Scientific Evaluation of Processing Excipients of Sizhi Leonuri Herba Based on Pharmacodynamic Ingredients

作　　者：甘国兴 朱卫星 龙国斌 向燕芬 陈小锐 陈海明 李润虹 GAN Guoxing;ZHU Weixing;LONG Guobin;XIANG Yanfen;CHEN Xiaorui;CHEN Haiming;LI Runhong(Fresh and Ethnic Medicine Engineering Technology Research Center of Guangdong Province,Qingyuan Hospital of Traditional Chinese Medicine,Qingyuan 511500,China;Department of Pharmacy,Qingyuan Hospital of Traditional Chinese Medicine,Qingyuan 511500,China;Food and Drug Inspection Institute of Qingyuan,Qingyuan 511500,China)

机构地区：[1]清远市中医院广东省鲜药民族医药工程技术研究中心,广东清远511500 [2]清远市中医院药学部,广东清远511500 [3]清远市食品药品检验所,广东清远511500

出　　处：《中国现代应用药学》2021年第5期572-575,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：广东省中医药局中医药科研项目(20191405)。

摘　　要：目的通过研究不同炮制辅料对益母草药效成分的影响,评价四制益母草炮制辅料的科学性。方法采用HPLC按照中国药典2015年版中"益母草"项下含量测定方法测定不同辅料炮制的四制益母草中盐酸益母草碱和盐酸水苏碱的含量,分析不同炮制辅料对益母草中盐酸益母草碱和盐酸水苏碱含量的影响。结果姜酒醋童便炮制的四制益母草中盐酸益母草碱的含量高于姜酒醋盐炮制的四制益母草,两者的盐酸水苏碱的含量相当。结论四制益母草的炮制辅料选择姜酒醋童便具有一定的优势,后续将进一步研究童便优于盐的成分机制,探索童便的替代辅料。OBJECTIVE To evaluate the scientificity of processing excipients of Sizhi Leonuri Herba by study the effects of different processing excipients on the active ingredients of Sizhi Leonuri Herba.METHODS Content of leonurine hydrochloride and stachyine hydrochloride in Sizhi Leonuri Herba prepared with different excipients was determined by HPLC according to the content determination method of“Leonuri Herba”in Chinese Pharmacopoeia 2015 edition.The effect of different processing excipients on the content of leonurine hydrochloride and stachyine hydrochloride was analyzed.RESULTS The content of leonurine hydrochloride of Sizhi Leonuri Herba made with ginger,wine,vinegar and child’s piss was higher than which made with ginger,wine,vinegar and salt.The content of stachyine hydrochloride of Sizhi Leonuri Herba processed with different excipients was comparable.CONCLUSION Sizhi Leonuri Herba made with ginger,wine,vinegar and child’s piss has certain advantages,and the composition mechanism of child’s piss superior to salt will be further studied in the future,and the substitution of child’s piss as auxiliary material will be explored.

关 键 词：益母草 盐酸水苏碱 盐酸益母草碱 科学性 

分 类 号：R283.2[医药卫生—中药学]