沙格列汀对2型糖尿病患者平均血糖波动幅度、HOMA表达、β细胞功能的影响  

Effect of Saxagliptin on the Mean Blood Glucose Fluctuation Range,HOMA Expression andβ-cell Function in Patients with Type 2 Diabetes Mellitus

作　　者：惠媛 尹冬 闵冬雨[2] HUI Yuan;YIN Dong;MIN Dongyu(Department of Endocrinology Medicine,The First People’s Hospital of Lianyungang&Xuzhou Medical University Affiliated Hospital of Lianyungang&The First Affiliated Hospital of Kangda College of Nanjing Medical University,Lianyungang 222000,China;Experimental Center of Traditional Chinese Medicine,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)

机构地区：[1]徐州医科大学附属连云港医院,南京医科大学康达学院第一附属医院(连云港市第一人民医院)内分泌科,江苏连云港222000 [2]辽宁中医药大学附属医院中医药实验中心,沈阳110032

出　　处：《中国现代应用药学》2021年第5期619-623,共5页Chinese Journal of Modern Applied Pharmacy

基　　金：中国博士后科学基金项目(2014M551121);辽宁中医药大学脏象理论及应用国家教育部重点实验室基础基金项目(LZ2014043);连云港市卫生科技项目(201510)。

摘　　要：目的评价沙格列汀对2型糖尿病患者血糖波动的调节作用。方法将145例患者随机分为3组,沙格列汀低剂量(SG-L)组、沙格列汀高剂量(SG-H)组、二甲双胍(MG)组,分别给予二甲双胍1500mg+沙格列汀2.5mg、二甲双胍1 500 mg+沙格列汀5 mg、二甲双胍(1 500~2 000 mg)进行治疗。干预后检测其血糖水平、动态血糖及胰岛功能。结果治疗后,与MG组相比,SG-H组在早餐后2 h、午餐前、午餐后2 h、晚餐前、晚餐后2 h及晚餐后4 h血糖明显降低(P<0.05);平均血糖波动幅度、血糖水平标准差、最大血糖波动幅度、平均血糖水平明显降低(P<0.05);胰岛素β功能指数明显升高,胰岛素抵抗指数、空腹胰岛素水平均明显降低(P<0.05)。结论沙格列汀联合二甲双胍能有效控制不同时间点患者血糖,减少患者血糖波动,同时改善胰岛素β细胞功能,改善2型糖尿病患者的胰岛素抵抗。OBJECTIVE To evaluate the effect of saxagliptin on the regulation of blood glucose fluctuations in patients with type 2 diabetes mellitus.METHODS One hundred forty-five patients were randomly divided into 3 groups,saxagliptin low-dose(SG-L)group,saxagliptin high-dose(SG-H)group,and metformin(MG)group,gave metformin 1500 mg+saxagliptin 2.5 mg,metformin 1500 mg+saxagliptin 5 mg,and metformin(1500−2000 mg),respectively.The glucose level,dynamic glucose and pancreas islet function were measured.RESULTS After treatment,compared with the MG group,the blood glucose of the SG-H group was significantly reduced 2 h after breakfast,before lunch,2 h after lunch,and before dinner,2 h after dinner and 4 h after dinner(P<0.05);mean blood glucose fluctuation range,standard deviation of blood glucose level,maximum blood glucose fluctuation range,the mean blood glucose level value was significantly reduced(P<0.05);HOMA-βlevels was significantly increased,HOMA-IR and fasting insulin levels were reduced significant(P<0.05).CONCLUSION Saxagliptin combined with metformin can effectively control glucose in patients at different time points,reduce glucose fluctuation,while improving insulinβ-cell function,improving insulin resistance in patients with type 2 diabetes mellitus.

关 键 词：二肽基肽酶-4 沙格列汀 二甲双胍 2型糖尿病 血糖波动 

分 类 号：R969.4[医药卫生—药理学]