硝唑尼特抗病毒研究进展  

Research progress on antiviral effects of nitazoxanide

作　　者：齐力斌 杨月武 程梓桓 叶伟 QI Li-bin;YANG Yue-wu;CHENG Zi-huan;YE Wei(Cadets′team,School of Basic Medicine Sciences,Airforce Military Medical University,Shaanxi 710000,China;不详)

机构地区：[1]空军军医大学基础医学院学员队,陕西西安710000 [2]空军军医大学基础医学院微生物与病原生物学教研室,陕西西安710000

出　　处：《中国病毒病杂志》2021年第2期144-149,共6页Chinese Journal of Viral Diseases

基　　金：病原微生物生物安全国家重点实验室开放基金(SKLPBS1834);空军军医大学军事医学提升计划项目(2018JSTS03)。

摘　　要：硝唑尼特(nitazoxanide, NTZ)是一种四氢噻唑类(thiazolidine, TZD)化合物,起初被用于治疗绦虫感染,后又被用于治疗隐孢子虫、贾第鞭毛虫、阿米巴原虫等引起的腹泻。研究偶然发现硝唑尼特可以抑制人类免疫缺陷病毒(human immunodeficiency virus, HIV)的复制,后续研究陆续发现硝唑尼特对多种DNA病毒和RNA病毒,包括埃博拉病毒(ebola virus, EBOV)和乙型肝炎病毒(hepatitis B virus, HBV)等都具有显著的抗病毒活性。硝唑尼特的抗病毒机制包括通过增强固有免疫应答、影响病毒蛋白功能等机制抑制病毒复制。本文主要综述当前硝唑尼特及其代谢产物替唑尼特(tizoxanide, TIZ)抑制病毒的研究进展及可能的作用机制。Nitazoxanide(NTZ) is a thiazolidine(TZD) compound that was used initially to treat tapeworm infections, and later used to treat diarrhea caused by Cryptosporidium, Giardia, Amoeba, and etc.Accidentally, NTZ was discovered to inhibit the replication of HIV.Subsequent studies found that NTZ demonstrated significant antiviral activity against a variety of DNA and RNA viruses including Ebola virus and hepatitis B virus.The antiviral mechanisms of NTZ include enhancing the innate immune response and affecting the function of viral proteins to inhibit virus replication.In this review, we briefly summarize the research progress of NTZ and its metabolite tizoxanide(TIZ) on inhibiting the virus and its possible mechanism of action.

关 键 词：硝唑尼特 替唑尼特 四氢噻唑类化合物 抗病毒药物 新型冠状病毒 埃博拉病毒 乙型肝炎病毒 研究进展 

分 类 号：R978.61[医药卫生—药品]