中国2008~2018年孕产妇丙型肝炎病毒抗体阳性率的Meta分析  

Meta-analysis on the positive rate of hepatitis C antibody among pregnant females in China from 2008 to 2018

作　　者：马晶 曹文珮 王梅[2] 谯小伟[3] 李娟生[1] 任晓卫[1] 刘小宁[1] MA Jing;CAO Wenpei;WANG Mei;QIAO Xiaowei;LI Juansheng;REN Xiaowei;LIU Xiaoning(Department of Epidemiology and Biostatistics,School of Public Health,Lanzhou University,Lanzhou 730000,P.R.China;Gansu Provincial Maternity and Child-care Hospital,Lanzhou 730000,P.R.China;Lanzhou Center for Disease Prevention and Control,Lanzhou 730000,P.R.China)

机构地区：[1]兰州大学公共卫生学院流行病与卫生统计所,兰州730000 [2]甘肃省妇幼保健院,兰州730000 [3]兰州市疾病预防控制中心,兰州730000

出　　处：《中国循证医学杂志》2021年第4期394-400,共7页Chinese Journal of Evidence-based Medicine

基　　金：兰州市人才创新创业项目(编号:2018-RC-53)。

摘　　要：目的系统评价2008~2018年中国大陆孕产妇人群丙型肝炎病毒(hepatitis C virus,HCV)抗体阳性率,为孕产妇人群HCV的防治策略提供科学依据。方法计算机检索PubMed、Web of Science、SinoMed、CNKI、VIP和WanFang Data数据库,搜集2008年1月至2018年12月中国大陆孕产妇人群HCV抗体阳性率的横断面研究,检索时限均为建库至2020年8月30日。由2名评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 15.0软件进行Meta分析。结果共纳入108个研究,总样本量为657765例。Meta分析结果显示,中国大陆孕产妇人群HCV抗体合并阳性率为0.235%[95%CI(0.189%,0.286%)]。西部地区孕产妇人群HCV抗体阳性率最高为0.291%[95%CI(0.221%,0.378%)],其次为东北地区0.240%[95%CI(0.099%,0.442%)]和中部地区0.235%[95%CI(0.016%,0.319%)];东部地区最低为0.193%[95%CI(0.119%,0.281%)]。医院病例报告来源的孕产妇HCV抗体阳性率0.291%[95%CI(0.221%,0.372%)]高于艾滋病哨点监测人群0.164%[95%CI(0.122%,0.207%)]。结论中国大陆孕产妇人群HCV抗体阳性率维持在相对较低水平。Objective To perform a meta-analysis on the positive rate of hepatitis C virus(HCV)antibody among pregnant females in China from 2008 to 2018,so as to provide scientific references for the prevention and treatment of HCV infection among pregnant females.Methods Databases including PubMed,Web of Science,SinoMed,CNKI,VIP,and WanFang Data were electronically searched to collect observational studies on the positive rate of HCV antibody among pregnant females in China from January,2008 to December,2018.Two reviewers independently screened literature,extracted data and evaluated risk of bias of included studies.Meta-analysis was then performed using Stata 15.0 software.Results A total of 108 studies involving 657765 individuals were included.Results of meta-analysis showed that the overall positive rate of HCV antibody among pregnant females in Chinese was 0.235%(95%CI 0.189%to0.286%).Subgroup analysis showed that the positive rate of HCV antibody among pregnant females in western China to be the highest 0.291%(95%CI 0.221%to 0.378%),the northeast China to be 0.240%(95%CI 0.099%to 0.442%),the central China to be 0.235%(95%CI 0.016%to 0.319%),and the east China to be the lowest 0.193%(95%CI 0.119%to 0.281%).The HCV antibody positive rate of pregnant females from hospital was 0.291%(95%CI 0.221%to 0.372%)and was higher than that from AIDS surveillance site which was 0.164%(95%CI 0.122%to 0.207%).Conclusions The prevalence of HCV antibody among pregnant females maintains at a low level in China.

关 键 词：丙型肝炎抗体 孕产妇 阳性率 META分析 

分 类 号：R714.251[医药卫生—妇产科学]