中国40岁及以上人群骨关节炎患病率的Meta分析  

The prevalence of osteoarthritis in Chinese aged 40 and over: a meta-analysis

作　　者：张莹莹[1] 李旭东[1] 杨佳娟[2] 马丽 陈岳伟 ZHANG Yingying;LI Xudong;YANG Jiajuan;MA Li;CHEN Yuewei(Office of Epidemiology,Chinese Center for Disease Control and Prevention,Beijing 102206,P.R.China;Yichang Center for Disease Control and Prevention,Yichang 443000,P.R.China)

机构地区：[1]中国疾病预防控制中心流行病学办公室,北京102206 [2]宜昌市疾病预防控制中心,湖北宜昌443000

出　　处：《中国循证医学杂志》2021年第4期407-414,共8页Chinese Journal of Evidence-based Medicine

基　　金：国家重大科学研究计划(编号:2012CB955500、2012CB955504)。

摘　　要：目的系统评价2000年1月至2019年12月中国40岁及以上人群骨关节炎患病率。方法计算机检索PubMed、ScienceDirect、Wiley Online Library、The Cochrane Library、CBM、VIP、CNKI和WanFang Data数据库,搜集有关中国40岁以上人群骨关节炎患病率的横断面研究,检索时限均为2000年1月1日至2019年12月31日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用R 3.5.2软件进行Meta分析。结果共纳入29个横断面研究,样本总量60711例,患病人数19707例。Meta分析结果显示,中国40岁及以上人群骨关节炎粗患病率为38.46%[95%CI(24.31%,46.22%)]。亚组分析结果显示,腰椎骨关节炎患病率24.79%[95%CI(13.28%,27.37%)]最高;膝骨关节炎患病率20.50%[95%CI(14.51%,27.23%)]次之,且随年龄升高而升高。女性膝骨关节炎患病率为25.14%[95%CI(19.54%,31.19%)]高于男性的18.99%[95%CI(13.86%,24.71%)];膝、腰椎骨关节炎患病率农村均高于城市。西部地区膝骨关节炎患病率为23.59%[95%CI(18.34%,30.35%)]高于东部的18.63%[95%CI(12.43%,27.92%)]和中部地区的15.54%[95%CI(11.22%,21.53%)]。西部地区腰椎骨关节炎患病率为31.17%[95%CI(19.21%,50.60%)]高于东部地区的24.38%[95%CI(16.26%,36.54%)]。东部颈椎骨关节炎患病率为20.49%[95%CI(13.90%,30.21%)]高于西部地区的12.32%[95%CI(8.09%,18.75%)]。西部地区手骨关节炎患病率为6.85%[95%CI(2.71%,8.13%)]高于东部地区的2.7%[95%CI(1.33%,5.48%)]。结论现有证据表明,中国40岁及以上人群骨关节炎患病率较高,其中腰椎骨关节炎患病率最高,西部患病率高于东部与中部地区;其次为膝骨关节炎,女性、农村、西部地区人群患病率较高。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。Objective To systematically review the prevalence of osteoarthritis in Chinese aged 40 and above from January 2000 to December 2019.Methods PubMed,ScienceDirect,Wiley Online Library,The Cochrane Library,CBM,VIP,CNKI and WanFang Data databases were electronically searched to collect cross-sectional studies on osteoarthritis in Chinese aged 40 and above from January 1 st,2000 to December 31 st,2019.Two reviewers independently screened literature,extracted data and assessed risk of bias of included studies.Meta-analysis was then performed using R3.5.2 software.Results A total of 29 cross-sectional studies with a total sample of 60711 cases and 19707 patients were included.The results of meta-analysis showed that,the crude prevalence of osteoarthritis in Chinese aged 40 and over was38.46%(95%CI 24.31%to 46.22%).Subgroup analysis results showed that the prevalence of lumbar osteoarthritis was the highest(24.79%,95%CI 13.28%to 27.37%),followed by knee osteoarthritis prevalence(20.50%,95%CI 14.51%to 27.23%)which increased with age.The prevalence of knee osteoarthritis in females(25.14%,95%CI 19.54%to31.19%)was higher than that in males(18.99%,95%CI 13.86%to 24.71%).The prevalence of knee and lumbar osteoarthritis in rural areas was higher than that in urban areas.The prevalence of knee osteoarthritis in western China(23.59%,95%CI 18.34%to 30.35%)was higher than that in eastern China(18.36%,95%CI 12.43%to 27.92%)and central China(15.54%,95%CI 11.22%to 21.53%).The prevalence of lumbar osteoarthritis in western China(31.17%,95%CI19.21%to 50.60%)was higher than that in eastern China(24.38%,95%CI 16.26%to 36.54%).The incidence of cervical osteoarthritis in the eastern China(20.49%,95%CI 13.90%to 30.21%)was higher than that in the western China(12.32%95%CI 8.09%to 18.75%).The prevalence of hand osteoarthritis in western China(6.85%,95%CI 2.71%to 8.13%)was higher than that in eastern China(2.7%,95%CI 1.33%to 5.48%).Conclusions Current evidence shows that the prevalence of osteoarthritis in Chinese aged 40 and above is high,and

关 键 词：中国 骨关节炎 中老年人 患病率 META分析 系统评价 横断面研究 

分 类 号：R684.3[医药卫生—骨科学]