针刺合谷穴后前额叶脑功能血氧水平依赖信号与神经递质谷氨酸及谷氨酰胺复合物的关系  

Brain function blood oxygen level dependent signal andneurotransmitter glutamine and glutamate complex inprefrontal lobe during acupuncturing Hegu (LI4)

作　　者：赵彦萍[1] 陈媛媛[1] 方继良[1] 洪洋[1] 王寅[2] 王珺 许可 李小娇[1] 孙黎[1] 陈丽梅 张国雷 罗萍[1] 王智 ZHAO Yanping;CHEN Yuanyuan;FANG Jiliang;HONG Yang;WANG Yin;WANG Jun;XU Ke;LI Xiaojiao;SUN Li;CHEN Limei;ZHANG Guolei;LUO Ping;WANG Zhi(Department of Radiology,Guang'anmen Hospital China Academy of Chinese Medical Sciences,Beijing 100053,China;Department of Acupunture-Moxibustion,Guang'anmen Hospital China Academy of Chinese Medical Sciences,Beijing 100053,China;Department of Acupunture-Moxibustion,Beijing Chinese Medicine Hospital Pinggu Hospital,Beijing 101200,China)

机构地区：[1]中国中医科学院广安门医院放射科,北京100053 [2]中国中医科学院广安门医院针灸科,北京100053 [3]北京中医院平谷医院针灸科,北京101200

出　　处：《中国医学影像技术》2021年第4期497-501,共5页Chinese Journal of Medical Imaging Technology

基　　金：科技部重点研发计划(2018YFC1705802);国家自然科学基金面上项目(81774433、81273674);中国中医科学院广安门医院所级科研基金(2016s355)。

摘　　要：目的观察针刺右侧合谷穴时前额叶血氧水平依赖(BOLD)信号、较正后谷氨酸谷氨酰胺复合物(GLx+)浓度及其相关性。方法对76名健康受试者采集静息及刺激[手针及纤毛机械刺激针(纤毛针)]合谷穴时BOLD功能MRI(fMRI)及磁共振波谱(MRS)数据,分析BOLD信号定量值与Glx^(+)浓度的相关性。结果手针较纤毛针针刺激发更多负激活,以前额叶内侧皮层(mPFC)及前扣带回(ACC)为著。2组BOLD信号定量值差异和Glx^(+)浓度差异均无统计学意义(P均>0.05)。BOLD定量信号与Glx^(+)浓度均无明显相关(P均>0.05),刺激前后Glx^(+)浓度差异均无统计学意义(P均>0.05)。结论手针针刺合谷穴诱发边缘叶-旁边缘叶-新皮层网络负激活效应,手针和纤毛针刺激前后Glx^(+)浓度多无明显变化;BOLD信号定量值与Glx^(+)浓度无明显相关。Objective To explore the blood oxygen level dependent(BOLD)signal,corrected glutamine and glutamate complex(GLx+)concentration and their correlation in the prefrontal lobe during acupuncture at right Hegu(LI4).Methods Totally 76 healthy volunteers were recruited.Data of BOLD functional MRI(fMRI)and MR spectroscopy(MRS)were collected during resting and stimulated(acupuncture and Von Frey hairs)at Hegu.The correlations of quantified BOLD signals and Glx^(+)concentrations were calculated.Results Acupuncture induced more intensive and extensive BOLD deactivation especially in medial prefrontal cortex(mPFC)and anterior cingulate cortex(ACC).No statistical difference of quantified BOLD signal nor Glx^(+)concentration was observed between 2 stimulation methods(all P>0.05).The quantified BOLD signals were not significantly correlated with Glx^(+)concentrations(all P>0.05),and no statistical difference of Glx^(+)concentrations was found before and after stimulations of Hegu(all P>0.05).Conclusion Acupuncture at Hegu induced deactivation in the limbic-paralimbic-neuocortical network.Glx^(+)concentrations remained stable before and after stimulations in most situations.The quantified BOLD signals were not correlated with Glx^(+)concentrations.

关 键 词：磁共振成像 血氧水平依赖 磁共振波谱 谷氨酸 谷氨酰胺 针刺 合谷 

分 类 号：R338.2[医药卫生—人体生理学] R445.2[医药卫生—基础医学]