四氢叶酸还原酶基因多态性与中国妇女先兆流产关系meta分析  

Association between MTHFR gene polymorphisms and threatened abortion of women:a meta-analysis

作　　者：周青 刘帅妹 张瑞金 石慧 林宁 吴玉璘 ZHOU Qing;LIU Shuaimei;ZHANG Ruijin;SHI Hui;LIN Ning;WU Yulin(Jiangsu Health Development Research Center,Nanjing,Jiangsu Province,210036)

机构地区：[1]江苏省卫生健康发展研究中心,南京210036

出　　处：《中国计划生育学杂志》2021年第3期428-431,共4页Chinese Journal of Family Planning

基　　金：江苏省科技厅创新能力建设计划(科技设施类)—省属公益类科研院所自主科研经费(省科技厅,BM2018033-3);江苏省计划生育科学技术研究所启动基金项目(JSFP-2018003)。

摘　　要：目的:探讨亚甲基四氢叶酸还原酶基因多态性与中国妇女先兆流产的关系。方法:检索万方、中国知网和Pubmed等中英文数据库,截止时间至2020年8月10日。经筛选最终纳入7篇文献。采用State软件进行数据分析,计算95%可信度区间和比值比评估两者关系并行异质性检测和发表偏倚评估。结果:MTHFR(C677T)基因T与COR=1.13,95%CI 1.06~1.20,Ph=0.902;TT与CCOR=1.19,95%CI 1.05~1.35,Ph=0.379;TT与(CC+CT)OR=1.19,95%CI 1.06~1.34,Ph=0.955。提示MTHFR(C677T)基因多态性与中国妇女先兆流产存在明显相关性。而MTHFR(A1298C)基因5种遗传模型在两组间差异均无统计学意义。结论:MTHFR(C677T)基因多态性可能增加中国妇女先兆流产的风险,而MTHFR(A1298C)基因多态性可能与中国妇女先兆流产不存在相关性。Objective:To investigate the relationship between gene the polymorphism methylene of tetrahydrofolate reductase of Chinese women and their threatened abortion,and to provide effective evidence for better prevention and treatment of threatened abortion.Methods:The databases,such as Wanfang,CNKI and Pubmed,were searched until August 10,2020.And a total of 7papers were included in this meta-analysis.State software was used to evaluate the relationship between them by 95%confidence interval,odds ratio,publication bias,and heterogeneity.Results:For the MTHFR(C677T)gene,there were significance associations in the comparison T vs.C(OR=1.13,95%CI:1.06-1.20,Ph=0.902),TT vs.CC(OR=1.19,95%CI:1.05-1.35,Ph=0.379),and TT vs.CC+CT(OR=1.19,95%CI:1.06-1.34,Ph=0.955).For the MTHFR(A1298C)gene,there were no significance associations in the comparison above.Conclusion:MTHFR(C677T)gene polymorphism may increase the risk of threatened abortion.However,MTHFR(A1298C)gene polymorphism may not be associated with threatened abortion.

关 键 词：先兆流产 多态性 亚甲基四氢叶酸:文献分析 

分 类 号：R714.21[医药卫生—妇产科学]