宫瘤消胶囊辅助治疗子宫内膜异位症痛经效果及对患者血清PGE2、PGF2α、NGF、OT影响  

Efficacy of Gongliuxiao capsule for adjuvant treating women with dysmenorrhea because of endometriosis and its influence on their serum levels of PGE2,PGF2α,NGF,and OT

作　　者：陈晓辉 常春艳 赵艳 CHEN Xiaohui;CHANG Chunyan;ZHAO Yan(Baoshan District Integrated Traditional Chinese and Western Medicine Hospital,Shanghai,201900)

机构地区：[1]上海市宝山区中西医结合医院,201900

出　　处：《中国计划生育学杂志》2021年第3期447-451,共5页Chinese Journal of Family Planning

基　　金：上海市中医妇科能力建设项目(沪卫计中管[2017]21号);上海市中医优势病种培育建设项目[ZY(2018-2020)-ZYBZ-22]。

摘　　要：目的:探讨宫瘤消胶囊辅助治疗子宫内膜异位症(EMS)痛经疗效及对血清前列腺素E2(PGE2)、前列腺素F2α(PGF2α)、神经生长因子(NGF)、催产素(OT)影响。方法:将127例EMS痛经患者随机分为对照组(n=62)与观察组(n=65),对照组给予孕三烯酮+米非司酮治疗、观察组在对照组基础上加用宫瘤消胶囊辅助治疗3个月。比较两组疗效并评估中文版COX痛经症状评分量表(CMSS)、疼痛视觉模拟量表(VAS)评分,测量子宫体积、子宫内膜厚度与包块直径,检测血清PGE2、PGF2α、NGF、OT、癌抗原125(CA125)、血管内皮生长因子(VEGF)、转化生长因子α1(TGF-α1)。结果:治疗后,观察组总有效率(96.9%)高于对照组(83.9%),CMSS评分、VAS评分、子宫体积、子宫内膜厚度与包块直径均较治疗前及对照组显著降低,且血清PGE2、PGF2α、NGF、OT、CA125、VEGF、TGF-α1水平均较治疗前及对照组显著降低(均P<0.05)。结论:宫瘤消胶囊辅助治疗EMS痛经疗效更佳,可缓解痛经及伴随症状,机制可能与下调PGE2、PGF2α、NGF、OT水平有关。Objective:To explore the efficacy of Gongliuxiao Capsules for adjuvant treating women with dysmenorrhea because of endometriosis(EMS),and to study its influence on serum levels of prostaglandin E2(PGE2),prostaglandin F2α(PGF2α),nerve growth factor(NGF),and oxytocin(OT)of the women.Methods:127 women with dysmenorrhea because of EMS were randomly divided into control group(n=62)and observation group(n=65).The women in the control group were treated with gestrinone and mifepristone for 3 months,and the women in the observation group were treated with supplemented with Gongliuxiao capsule treatment combined with gestrinone and mifepristone for 3 months.The efficacy of the women was compared between the two groups.The scores of the Chinese version of COX dysmenorrhea symptom scale(CMSS)and pain visual analog scale(VAS)of the women in the two groups were evaluated,the uterine volume,endometrial thickness and mass diameter of the women in the two groups after treatment was measured,and the serum levels of PGE2,PGF2α,NGF,OT,cancer antigen 125(CA125),vascular endothelial growth factor(VEGF),and transforming growth factorα1(TGF-α1)of the women in the two groups were detected.Results:After treatment,the total effective rate of the women in the observation group(96.9%)was significant higher than that(83.9%)of the women in the control group,and the CMSS score,VAS score,uterine volume,endometrial thickness,mass diameter,the serum levels of PGE2,PGF2α,NGF,OT,CA125,VEGF,and TGF-α1 of the women in the observation group were significant lower than those before treatment and than those of the women in the control group(P<0.05).Conclusion:Gongliuxiao capsule for adjuvant treating women with dysmenorrhea because of EMS has definite effect,which can relieve dysmenorrhea and accompanying symptoms.The mechanism may be related to the down-regulation of PGE2,PGF2α,NGF and OT levels of the women.

关 键 词：子宫内膜异位症 痛经 宫瘤消胶囊 前列腺素E2 前列腺素F2Α 神经生长因子 催产素 

分 类 号：R711.71[医药卫生—妇产科学]