枸橼酸氯米芬胶囊联合胰岛素增敏剂治疗多囊卵巢综合征疗效  

Efficacy of clomiphene citrate capsules combined with insulin sensitizer for treating women with polycystic ovary syndrome

作　　者：姚晓燕[1] 唐爽[1] 陈欣[1] 蒋燕[1] 谭建春[1] 杨琴[1] 吕连华 YAO Xiaoyan;TANG Shuang;CHEN Xin;JIANG Yan;TAN Jianchun;YANG Qin;LV Lianhua(Mianyang People's Hospital,Sichuan Province,621000)

机构地区：[1]四川省绵阳市人民医院,621000

出　　处：《中国计划生育学杂志》2021年第3期492-494,共3页Chinese Journal of Family Planning

基　　金：四川省卫生计生委科研课题(140038)。

摘　　要：目的:观察枸橼酸氯米芬胶囊联合胰岛素增敏剂治疗多囊卵巢综合征(PCOS)疗效及对抗苗勒管激素(AMH)和受孕率的影响。方法:选取2015年1月—2019年1月在本院就诊的PCOS患者80例,随机分两组各40例,对照组采用枸橼酸氯米芬胶囊治疗,观察组在此基础上联合胰岛素增敏剂治疗。比较两组患者治疗前后血清性激素[促卵泡生长激素(FSH)、促黄体生成素(LH)、雌二醇(E2)]和AMH变化,治疗后疗效和妊娠结局。结果:治疗3个月经周期后,观察组治疗总有效率(97.5%)高于对照组(82.5%)(P<0.05);两组血清FSH、LH、E2和AMH水平均较治疗前降低,且观察组低于对照组(P<0.05);随访1年,观察组排卵率(85.0%)、妊娠率(73.5%)均高于对照组(62.5%、36.0%),早孕流产率(0.0%)低于对照组(22.2%)(P<0.05)。结论:枸橼酸氯米芬胶囊联合胰岛素增敏剂治疗PCOS可增强疗效,改善性激素水平,促进排卵,提高受孕率。Objective:To observe the efficacy of clomiphene citrate capsules combined with insulin sensitizer for treating women with polycystic ovary syndrome(PCOS),and to study its effects on anti-Müllerian hormone(AMH)level and pregnancy rate of the women after treatment.Methods:80 women with PCOS were selected and were random divided into two groups(40 cases in each group)from January 2015 to January 2019.The women in the control group were treated by clomiphene citrate capsules,and the women in the observation group were treated by clomiphene citrate capsules combined with insulin sensitizer.The changes of the levels of serum sex hormones follicular growth hormone(FSH),luteinizing hormone(LH),estradiol(E2),and AMH before and after treatment,and curative effect and pregnancy outcomes,such as ovulation rate,pregnancy rate,and early abortion rate,of the women were compared between the two groups.Results:After 3 months of treatment,the total effective rate(97.5%)of the women in the observation group was significant higher than that(82.5%)of the women in the control group(P<0.05).The levels of serum FSH,LH and E2 of the women in the two groups had decreased significantly after treatment,and which of the women in the observation group were significant lower than those of the women in the control group(P<0.05).After 1 year of followed up,the ovulation rate(85.0%)and pregnancy rate(73.5%)of the women in the observation group were significant higher than those(62.5%and 36.0%)of the women in the control group,but the early abortion rate(0.0%)of the women in the observation group was significant lower than that(22.2%)of the women in the control group(P<0.05).Conclusion:Clomiphene citrate capsules combined with insulin sensitizer for treating women with PCOS can enhance the efficacy,improve the hormones levels,promote their ovulation,and increase the pregnancy rate.

关 键 词：多囊卵巢综合征 枸橼酸氯米芬胶囊 胰岛素增敏剂 抗苗勒管激素 受孕率 

分 类 号：R711.75[医药卫生—妇产科学]