达英-35短期预处理联合高孕激素状态下促排卵方案用于卵巢储备功能减退效果  

Clinical effect of Diane-35 short-term used as pretreatment combined with PPOS regimen for treating patients with decreasing ovarian reserve

作　　者：胡玥玥[1] 何均 闫旭 张昌军[1,2] HU Yueyue;HE Jun;YAN Xu;ZHANG Changjun(Shiyan People's Hospital,Hubei Province,442000;Biomedical Research Institute,Hubei University of Medicine)

机构地区：[1]湖北省十堰市人民医院,442000 [2]湖北医药学院生物医学工程学院

出　　处：《中国计划生育学杂志》2021年第3期503-507,共5页Chinese Journal of Family Planning

基　　金：湖北省自然科学基金(2015CFB543);湖北医药学院生物医药研究院PI项目(HBMUPI201802)。

摘　　要：目的:探讨不同卵泡刺激素(FSH)水平、不同年龄的卵巢储备功能减退(DOR)患者应用达英-35短期预处理联合高孕激素状态下促排卵(PPOS)方案的临床效果。方法:回顾性分析2015年1月—2018年9月在湖北医药学院附属人民医院接受PPOS方案治疗的247例DOR患者的临床资料,其中使用达英-35短期预处理联合PPOS方案为观察组,直接应用PPOS方案为对照组,再根据基础FSH水平和年龄将观察组和对照组分别分为4组,比较观察各组与其对照组的Gn用量、Gn使用天数、获卵数、可利用胚胎数和优胚率。结果:观察各组Gn用量高于其对照组(P<0.01),获卵数均无统计学差异(P>0.05),在年龄≥35且<40岁,基础FSH>12且≤14mU/L患者中,观察组可利用胚胎数显著高于对照组(2.05±0.97 VS 1.23±1.09;P<0.05)。结论:年龄35~40岁、基础FSH>12且≤14 U/LDOR的患者,应用达英-35短期预处理联合PPOS方案,能增加可利用胚胎数,改善IVF治疗的促排卵结局。Objective:To investigate the effect of Diane-35 short-term used as pretreatment combined with high progestin primed ovarian stimulation(PPOS)regimen for treating patients with decreasing ovarian reserve(DOR)and different FSH levels and age.Methods:The clinical data of 247 patients with DOR treated by PPOS regimen from January 2015 to September 2018 were analyzed retrospectively.The women treated by Diane-35 short-term used as pretreatment combined with PPOS were in observation group,and the women treated by PPOS only were in control group.The women in the observation group and the control group were also divided into 4 groups according to their basal FSH level and age.The dosage of Gn used,the days of Gn used,the number of oocytes obtained,the number of embryos available,and the rate of high-quality embryos of the women were observed and compared among these groups.Results:The Gn dosage of the patients in the observation group was significantly higher than that of the patients in the control group(P<0.01).There was no significant difference in the number of retrieved eggs of the patients between the observation group and the control group(P>0.05).The number of available embryos of the patients aged 35-40 years old with basal FSH level>12 and≤14 U/L in the observation group was significantly higher than that of the patients in the control group(P<0.05).Conclusion:Diane-35 short-term used as pretreatment combined with PPOS regimen for treating the patients aged 35-40 years old with DOR and basal FSH level>12 and≤14 U/L can increase the number of available embryos and can improve the ovulation induction outcomes of IVF.

关 键 词：卵巢储备功能减退 体外受精 高孕激素 促排卵 达英-35 

分 类 号：R714.8[医药卫生—妇产科学]